Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM032637-14
Application #
2176675
Study Section
Special Emphasis Panel (NSS)
Project Start
1983-03-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Ryan, Daniel E; Kim, Chang Hee; Murray, James B et al. (2004) New tertiary constraints between the RNA components of active yeast spliceosomes: a photo-crosslinking study. RNA 10:1251-65
Perriman, Rhonda; Barta, Imre; Voeltz, Gia K et al. (2003) ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA. Proc Natl Acad Sci U S A 100:13857-62
Ryan, Daniel E; Abelson, John (2002) The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly. RNA 8:997-1010
Ryan, Daniel E; Stevens, Scott W; Abelson, John (2002) The 5' and 3' domains of yeast U6 snRNA: Lsm proteins facilitate binding of Prp24 protein to the U6 telestem region. RNA 8:1011-33
Story, R M; Li, H; Abelson, J N (2001) Crystal structure of a DEAD box protein from the hyperthermophile Methanococcus jannaschii. Proc Natl Acad Sci U S A 98:1465-70
Wagner, J D; Jankowsky, E; Company, M et al. (1998) The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes. EMBO J 17:2926-37
Arenas, J E; Abelson, J N (1997) Prp43: An RNA helicase-like factor involved in spliceosome disassembly. Proc Natl Acad Sci U S A 94:11798-802
Kim, C H; Ryan, D E; Marciniec, T et al. (1997) Site-specific deoxynucleotide substitutions in yeast U6 snRNA block splicing of pre-mRNA in vitro. EMBO J 16:2119-29
Kim, C H; Abelson, J (1996) Site-specific crosslinks of yeast U6 snRNA to the pre-mRNA near the 5' splice site. RNA 2:995-1010
O'Day, C L; Dalbadie-McFarland, G; Abelson, J (1996) The Saccharomyces cerevisiae Prp5 protein has RNA-dependent ATPase activity with specificity for U2 small nuclear RNA. J Biol Chem 271:33261-7

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