Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM033088-26
Application #
2176852
Study Section
Special Emphasis Panel (NSS)
Project Start
1979-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
26
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Shadel, G S; Buckenmeyer, G A; Clayton, D A et al. (2000) Mutational analysis of the RNA component of Saccharomyces cerevisiae RNase MRP reveals distinct nuclear phenotypes. Gene 245:175-84
Wang, J; Wilhelmsson, H; Graff, C et al. (1999) Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet 21:133-7
Wiesner, R J; Hornung, T V; Garman, J D et al. (1999) Stimulation of mitochondrial gene expression and proliferation of mitochondria following impairment of cellular energy transfer by inhibition of the phosphocreatine circuit in rat hearts. J Bioenerg Biomembr 31:559-67
Van Dyck, E; Clayton, D A (1998) Transcription-dependent DNA transactions in the mitochondrial genome of a yeast hypersuppressive petite mutant. Mol Cell Biol 18:2976-85
Larsson, N G; Wang, J; Wilhelmsson, H et al. (1998) Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet 18:231-6
Lee, D Y; Clayton, D A (1998) Initiation of mitochondrial DNA replication by transcription and R-loop processing. J Biol Chem 273:30614-21
Larsson, N G; Barsh, G S; Clayton, D A (1997) Structure and chromosomal localization of the mouse mitochondrial transcription factor A gene (Tfam). Mamm Genome 8:139-40
Lee, D Y; Clayton, D A (1997) RNase mitochondrial RNA processing correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication. Genes Dev 11:582-92
Shang, J; Li, X; Ring, H Z et al. (1997) Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft). Genomics 40:108-13
Shadel, G S; Clayton, D A (1997) Mitochondrial DNA maintenance in vertebrates. Annu Rev Biochem 66:409-35

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