Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM036944-11
Application #
2178601
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309
Nelson, Jennifer A; Shepotinovskaya, Irina; Uhlenbeck, Olke C (2005) Hammerheads derived from sTRSV show enhanced cleavage and ligation rate constants. Biochemistry 44:14577-85
Blount, Kenneth F; Grover, Neena L; Mokler, Victor et al. (2002) Steric interference modification of the hammerhead ribozyme. Chem Biol 9:1009-16
Dertinger, D; Uhlenbeck, O C (2001) Evaluation of methylphosphonates as analogs for detecting phosphate contacts in RNA-protein complexes. RNA 7:622-31
O'Rear, J L; Wang, S; Feig, A L et al. (2001) Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations. RNA 7:537-45
Dertinger, D; Dale, T; Uhlenbeck, O C (2001) Modifying the specificity of an RNA backbone contact. J Mol Biol 314:649-54
Dertinger, D; Behlen, L S; Uhlenbeck, O C (2000) Using phosphorothioate-substituted RNA to investigate the thermodynamic role of phosphates in a sequence specific RNA-protein complex. Biochemistry 39:55-63
Feig, A L; Panek, M; Horrocks Jr, W D et al. (1999) Probing the binding of Tb(III) and Eu(III) to the hammerhead ribozyme using luminescence spectroscopy. Chem Biol 6:801-10
Scott, E C; Uhlenbeck, O C (1999) A re-investigation of the thio effect at the hammerhead cleavage site. Nucleic Acids Res 27:479-84
Johansson, H E; Dertinger, D; LeCuyer, K A et al. (1998) A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein. Proc Natl Acad Sci U S A 95:9244-9
Tsu, C A; Uhlenbeck, O C (1998) Kinetic analysis of the RNA-dependent adenosinetriphosphatase activity of DbpA, an Escherichia coli DEAD protein specific for 23S ribosomal RNA. Biochemistry 37:16989-96

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