Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM037904-10
Application #
2179022
Study Section
Special Emphasis Panel (NSS)
Project Start
1986-07-01
Project End
2000-11-30
Budget Start
1995-12-15
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Lagree, Valerie; Brunschwig, Karin; Lopez, Patricia et al. (2003) Specific amino-acid residues in the N-terminus and TM3 implicated in channel function and oligomerization compatibility of connexin43. J Cell Sci 116:3189-201
Baruch, A; Greenbaum, D; Levy, E T et al. (2001) Defining a link between gap junction communication, proteolysis, and cataract formation. J Biol Chem 276:28999-9006
Baldo, G J; Gong, X; Martinez-Wittinghan, F J et al. (2001) Gap junctional coupling in lenses from alpha(8) connexin knockout mice. J Gen Physiol 118:447-56
Unger, V M; Kumar, N M; Gilula, N B et al. (1999) Expression, two-dimensional crystallization, and electron cryo-crystallography of recombinant gap junction membrane channels. J Struct Biol 128:98-105
Risek, B; Pozzi, A; Gilula, N B (1998) Modulation of gap junction expression during transient hyperplasia of rat epidermis. J Cell Sci 111 ( Pt 10):1395-404
Gong, X; Baldo, G J; Kumar, N M et al. (1998) Gap junctional coupling in lenses lacking alpha3 connexin. Proc Natl Acad Sci U S A 95:15303-8
Falk, M M; Gilula, N B (1998) Connexin membrane protein biosynthesis is influenced by polypeptide positioning within the translocon and signal peptidase access. J Biol Chem 273:7856-64
Falk, M M; Buehler, L K; Kumar, N M et al. (1997) Cell-free synthesis and assembly of connexins into functional gap junction membrane channels. EMBO J 16:2703-16
Risek, B; Gilula, N B (1996) Gap junction regulation during preterm labor in the rat: multiple effects of the antiprogesterone RU486. Biol Reprod 55:525-35
Buehler, L K; Stauffer, K A; Gilula, N B et al. (1995) Single channel behavior of recombinant beta 2 gap junction connexons reconstituted into planar lipid bilayers. Biophys J 68:1767-75

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