Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM037942-16
Application #
6193741
Study Section
Special Emphasis Panel (NSS)
Program Officer
Okita, Richard T
Project Start
1992-07-18
Project End
2006-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
16
Fiscal Year
2001
Total Cost
$282,831
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Oyama, Tsunehiro; Kagawa, Norio; Sugio, Kenji et al. (2009) Expression of aromatase CYP19 and its relationship with parameters in NSCLC. Front Biosci (Landmark Ed) 14:2285-92
Miller, Todd W; Shin, Incheol; Kagawa, Norio et al. (2008) Aromatase is phosphorylated in situ at serine-118. J Steroid Biochem Mol Biol 112:95-101
Tosha, Takehiko; Kagawa, Norio; Arase, Miharu et al. (2008) Interaction between substrate and oxygen ligand responsible for effective O-O bond cleavage in bovine cytochrome P450 steroid 21-hydroxylase proved by Raman spectroscopy. J Biol Chem 283:3708-17
Zollner, Andy; Kagawa, Norio; Waterman, Michael R et al. (2008) Purification and functional characterization of human 11beta hydroxylase expressed in Escherichia coli. FEBS J 275:799-810
Lamb, David C; Guengerich, F Peter; Kelly, Steven L et al. (2006) Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery. Expert Opin Drug Metab Toxicol 2:27-40
Lamb, David C; Kim, Youngchang; Yermalitskaya, Liudmila V et al. (2006) A second FMN binding site in yeast NADPH-cytochrome P450 reductase suggests a mechanism of electron transfer by diflavin reductases. Structure 14:51-61
Sherman, David H; Li, Shengying; Yermalitskaya, Liudmila V et al. (2006) The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. J Biol Chem 281:26289-97
Tosha, Takehiko; Kagawa, Norio; Ohta, Takehiro et al. (2006) Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome P450 aromatase during the three consecutive oxygen activation steps. Biochemistry 45:5631-40
Arase, Miharu; Waterman, Michael R; Kagawa, Norio (2006) Purification and characterization of bovine steroid 21-hydroxylase (P450c21) efficiently expressed in Escherichia coli. Biochem Biophys Res Commun 344:400-5
Zhao, Bin; Guengerich, F Peter; Voehler, Markus et al. (2005) Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer. J Biol Chem 280:42188-97

Showing the most recent 10 out of 81 publications