Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM038839-18
Application #
6779872
Study Section
Special Emphasis Panel (NSS)
Program Officer
Rhoades, Marcus M
Project Start
1988-08-01
Project End
2007-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
18
Fiscal Year
2004
Total Cost
$333,254
Indirect Cost
Name
Rockefeller University
Department
Biochemistry
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Georgescu, Roxana E; Schauer, Grant D; Yao, Nina Y et al. (2015) Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation. Elife 4:e04988
Sun, Jingchuan; Shi, Yi; Georgescu, Roxana E et al. (2015) The architecture of a eukaryotic replisome. Nat Struct Mol Biol 22:976-82
Georgescu, Roxana; Langston, Lance; O'Donnell, Mike (2015) A proposal: Evolution of PCNA's role as a marker of newly replicated DNA. DNA Repair (Amst) 29:4-15
Langston, Lance D; Zhang, Dan; Yurieva, Olga et al. (2014) CMG helicase and DNA polymerase ? form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication. Proc Natl Acad Sci U S A 111:15390-5
Marzahn, Melissa R; Hayner, Jaclyn N; Finkelstein, Jeff et al. (2014) The ATP sites of AAA+ clamp loaders work together as a switch to assemble clamps on DNA. J Biol Chem 289:5537-48
Georgescu, Roxana E; Yao, Nina; Indiani, Chiara et al. (2014) Replisome mechanics: lagging strand events that influence speed and processivity. Nucleic Acids Res 42:6497-510
Georgescu, Roxana E; Langston, Lance; Yao, Nina Y et al. (2014) Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork. Nat Struct Mol Biol 21:664-70
Indiani, Chiara; O'Donnell, Mike (2013) A proposal: Source of single strand DNA that elicits the SOS response. Front Biosci (Landmark Ed) 18:312-23
Pomerantz, Richard T; Goodman, Myron F; O'Donnell, Michael E (2013) DNA polymerases are error-prone at RecA-mediated recombination intermediates. Cell Cycle 12:2558-63
Kurth, Isabel; Georgescu, Roxana E; O'Donnell, Mike E (2013) A solution to release twisted DNA during chromosome replication by coupled DNA polymerases. Nature 496:119-22

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