Abstract

in instructions on page 6. X CAphpeeckndifix is included Appendix (Five collated sets. Nopage numbering necessary for Appendix.) Number of publications and manuscripts accepted or submitted for publication (not to exceed 10) 6 Other items (list): PHS 398 (Rev. 4/98) (Form Page 3) Page 3 CC Number pages consecutively at the bottomthroughout the application. Do not use suffixes such as 3a, 3b.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM043974-18
Application #
7740180
Study Section
Special Emphasis Panel (NSS)
Program Officer
Zatz, Marion M
Project Start
1990-04-01
Project End
2011-11-30
Budget Start
2009-12-01
Budget End
2010-11-30
Support Year
18
Fiscal Year
2010
Total Cost
$494,486
Indirect Cost

  Institution

Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125

  Publications

Kumagai, Akiko; Dunphy, William G (2017) MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication. Mol Biol Cell 28:2998-3012
Mu, Ruiling; Tat, John; Zamudio, Robert et al. (2017) CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin. Mol Cell Biol 37:
Guo, Cai; Kumagai, Akiko; Schlacher, Katharina et al. (2015) Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication. Mol Cell 57:492-505
Ryu, Hyunju; Yoshida, Makoto M; Sridharan, Vinidhra et al. (2015) SUMOylation of the C-terminal domain of DNA topoisomerase II? regulates the centromeric localization of Claspin. Cell Cycle 14:2777-84
Lee, Joon; Dunphy, William G (2013) The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. Mol Biol Cell 24:1343-53
Kumar, Sanjay; Yoo, Hae Yong; Kumagai, Akiko et al. (2012) Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. Cell Cycle 11:1183-94
Meng, Zheng; Capalbo, Luisa; Glover, David M et al. (2011) Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Mol Biol Cell 22:2834-47
Kumagai, Akiko; Shevchenko, Anna; Shevchenko, Andrej et al. (2011) Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. J Cell Biol 193:995-1007
Ramírez-Lugo, Juan S; Yoo, Hae Yong; Yoon, Su Jin et al. (2011) CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts. Cell Cycle 10:469-80
Wawrousek, Karen E; Fortini, Barbara K; Polaczek, Piotr et al. (2010) Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM. Cell Cycle 9:1156-66

Showing the most recent 10 out of 14 publications