Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM048259-17
Application #
6636066
Study Section
Special Emphasis Panel (NSS)
Program Officer
Rhoades, Marcus M
Project Start
1992-07-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
17
Fiscal Year
2003
Total Cost
$470,368
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Biology
Type
Other Domestic Higher Education
DUNS #
049179401
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Li, Huang; Wang, Zhijia; Zhou, Xuexia et al. (2013) Far upstream element-binding protein 1 and RNA secondary structure both mediate second-step splicing repression. Proc Natl Acad Sci U S A 110:E2687-95
Chen, Mo; Manley, James L (2009) Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol 10:741-54
Feng, Ying; Valley, Matthew T; Lazar, Josef et al. (2009) SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. Dev Cell 16:528-38
Ali, Gul Shad; Palusa, Saiprasad G; Golovkin, Maxim et al. (2007) Regulation of plant developmental processes by a novel splicing factor. PLoS One 2:e471
Li, Xialu; Niu, Tianhui; Manley, James L (2007) The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability. RNA 13:2108-15
Shi, Yongsheng; Reddy, Bharat; Manley, James L (2006) PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins. Mol Cell 23:819-29
Marin-Vinader, Laura; Shin, Chanseok; Onnekink, Carla et al. (2006) Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock. Mol Biol Cell 17:886-94
Li, Xialu; Wang, Jin; Manley, James L (2005) Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation. Genes Dev 19:2705-14
Li, Xialu; Manley, James L (2005) Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell 122:365-78
Millhouse, Scott; Manley, James L (2005) The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein. Mol Cell Biol 25:533-44

Showing the most recent 10 out of 21 publications