Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM052857-25
Application #
6711746
Study Section
Special Emphasis Panel (NSS)
Program Officer
Rodewald, Richard D
Project Start
1980-07-01
Project End
2006-02-28
Budget Start
2004-03-01
Budget End
2006-02-28
Support Year
25
Fiscal Year
2004
Total Cost
$337,065
Indirect Cost
Name
University of Pennsylvania
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Hegan, Peter S; Mermall, Valerie; Tilney, Lewis G et al. (2007) Roles for Drosophila melanogaster myosin IB in maintenance of enterocyte brush-border structure and resistance to the bacterial pathogen Pseudomonas entomophila. Mol Biol Cell 18:4625-36
Tilney, Lewis G; Connelly, Patricia S; Guild, Gregory M et al. (2005) Adaptation of a nematode parasite to living within the mammalian epithelium. J Exp Zool A Comp Exp Biol 303:927-45
Guild, Gregory M; Connelly, Patricia S; Ruggiero, Linda et al. (2005) Actin filament bundles in Drosophila wing hairs: hairs and bristles use different strategies for assembly. Mol Biol Cell 16:3620-31
Tilney, Lewis G; DeRosier, David J (2005) How to make a curved Drosophila bristle using straight actin bundles. Proc Natl Acad Sci U S A 102:18785-92
Tilney, Lewis G; Connelly, Patricia S; Guild, Gregory M (2004) Microvilli appear to represent the first step in actin bundle formation in Drosophila bristles. J Cell Sci 117:3531-8
Tilney, Lewis G; Connelly, Patricia S; Ruggiero, Linda et al. (2003) Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles. Mol Biol Cell 14:3953-66
Guild, Gregory M; Connelly, Patricia S; Ruggiero, Linda et al. (2003) Long continuous actin bundles in Drosophila bristles are constructed by overlapping short filaments. J Cell Biol 162:1069-77
Shaw, Michael K; Roos, David S; Tilney, Lewis G (2002) Cysteine and serine protease inhibitors block intracellular development and disrupt the secretory pathway of Toxoplasma gondii. Microbes Infect 4:119-32
Guild, Gregory M; Connelly, Patricia S; Vranich, Kelly A et al. (2002) Actin filament turnover removes bundles from Drosophila bristle cells. J Cell Sci 115:641-53
Tilney, L G; Harb, O S; Connelly, P S et al. (2001) How the parasitic bacterium Legionella pneumophila modifies its phagosome and transforms it into rough ER: implications for conversion of plasma membrane to the ER membrane. J Cell Sci 114:4637-50

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