Abstract

This is the continuation of a research program of long standing, designed to elucidate the neuroendocrine control systems which govern reproductive processes in the rhesus monkey, a representative primate. Much of what is learned using this experimental model has been and continues to be applicable to the understanding of human reproductive physiology. During the next project period the functioning of the hypothalamic LHRH pulse generator will be studied in unrestrained females throughout the normal menstrual cycle, pregnancy, lactation and the advent of puberty. The influence of mild pertubations in the environment will also be investigated. Pulse generator activity will be assessed using electrophyciological techniques couples with radiotelemetry permitting continuous monitoring of this control system in freely behaving animals. In addition, the ongoing study of the influence of various ovarian factors, other than estradiol and progesterone, on the hypothalamic LHRH pulse generator will be continued.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HD017438-08
Application #
3485114
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1982-07-01
Project End
1991-12-31
Budget Start
1989-01-01
Budget End
1989-12-31
Support Year
8
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
Overall Medical
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Chen, M D; Ordog, T; Knobil, E (1998) Mitigation of the somnolence of insulin-induced hypoglycemia by a vasopressin V1 receptor antagonist in the rhesus monkey. Psychoneuroendocrinology 23:497-503
Ordog, T; Chen, M D; O'Byrne, K T et al. (1998) On the mechanism of lactational anovulation in the rhesus monkey. Am J Physiol 274:E665-76
Ordog, T; Goldsmith, J R; Chen, M D et al. (1998) On the mechanism of the positive feedback action of estradiol on luteinizing hormone secretion in the rhesus monkey. J Clin Endocrinol Metab 83:4047-53
Ordog, T; Chen, M D; Nishihara, M et al. (1997) On the role of gonadotropin-releasing hormone (GnRH) in the operation of the GnRH pulse generator in the rhesus monkey. Neuroendocrinology 65:307-13
Chen, M D; Ordog, T; O'Byrne, K T et al. (1996) The insulin hypoglycemia-induced inhibition of gonadotropin-releasing hormone pulse generator activity in the rhesus monkey: roles of vasopressin and corticotropin-releasing factor. Endocrinology 137:2012-21
Ordog, T; Knobil, E (1995) Estradiol and the inhibition of hypothalamic gonadotropin-releasing hormone pulse generator activity in the rhesus monkey. Proc Natl Acad Sci U S A 92:5813-6
O'Byrne, K T; Chen, M D; Nishihara, M et al. (1993) Ovarian control of gonadotropin hormone-releasing hormone pulse generator activity in the rhesus monkey: duration of the associated hypothalamic signal. Neuroendocrinology 57:588-92
Grosser, P M; O'Byrne, K T; Williams, C L et al. (1993) Effects of naloxone on estrogen-induced changes in hypothalamic gonadotropin-releasing hormone pulse generator activity in the rhesus monkey. Neuroendocrinology 57:115-9
O'Byrne, K T; Knobil, E (1993) Electrophysiological approaches to gonadotrophin releasing hormone pulse generator activity in the rhesus monkey. Hum Reprod 8 Suppl 2:37-40
O'Byrne, K T; Thalabard, J C; Chiappini, S E et al. (1993) Ambient light modifies gonadotropin-releasing hormone pulse generator frequency in the rhesus monkey. Endocrinology 133:1520-4

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