Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HD019899-12
Application #
2197888
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1984-04-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Oregon Regional Primate Research Center
Department
Type
DUNS #
City
Beaverton
State
OR
Country
United States
Zip Code
97006
Zarinan, Teresa; Perez-Solis, Marco A; Maya-Nunez, Guadalupe et al. (2010) Dominant negative effects of human follicle-stimulating hormone receptor expression-deficient mutants on wild-type receptor cell surface expression. Rescue of oligomerization-dependent defective receptor expression by using cognate decoys. Mol Cell Endocrinol 321:112-22
Janovick, Jo Ann; Conn, P Michael (2010) Use of pharmacoperones to reveal GPCR structural changes associated with constitutive activation and trafficking. Methods Enzymol 485:277-92
Janovick, Jo Ann; Conn, P Michael (2010) Salt bridge integrates GPCR activation with protein trafficking. Proc Natl Acad Sci U S A 107:4454-8
Ayala Yanez, Rodrigo; Conn, P Michael (2010) Protein disulfide isomerase chaperone ERP-57 decreases plasma membrane expression of the human GnRH receptor. Cell Biochem Funct 28:66-73
Conn, P Michael; Ulloa-Aguirre, Alfredo (2010) Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs. Trends Endocrinol Metab 21:190-7
Re, Michelle; Pampillo, Macarena; Savard, Martin et al. (2010) The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane. PLoS One 5:e11489
Conn, P Michael; Janovick, Jo Ann (2009) Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease. Mol Cell Endocrinol 299:137-45
Lucca-Junior, W; Janovick, J A; Conn, P M (2009) Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane. Braz J Med Biol Res 42:164-7
Ulloa-Aguirre, Alfredo; Conn, P Michael (2009) Targeting of G protein-coupled receptors to the plasma membrane in health and disease. Front Biosci (Landmark Ed) 14:973-94
Conn, P Michael; Janovick, Jo Ann (2009) Drug development and the cellular quality control system. Trends Pharmacol Sci 30:228-33

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