Abstract

EXCEED THE SPACE PROVIDED. See Section D of the ResearchPlan PERFORMANCE SITE(S) (organization, city, state) The Jackson Laboratory Bar Harbor Maine Temple University School of Medicine Philadelphia Pennsylvania KEY PERSONNEL. See instructions. Use continuation pages as needed to provide the required information in the format shown below. Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on Project Eppig, John J. The Jackson Laboratory PI Latham, Keith E. Temple University School of Medicine Subcontract PI Disclosure Permission Statement. Applicable toSBIR/STTR Only. See instructions. I I Yes I I No PHS 398 (Rev. 05/01) Page 2 Form Page 2 ========================================Section End===========================================

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37HD021970-21
Application #
6937024
Study Section
Special Emphasis Panel (NSS)
Program Officer
Tasca, Richard J
Project Start
1986-09-01
Project End
2010-07-31
Budget Start
2005-09-01
Budget End
2006-07-31
Support Year
21
Fiscal Year
2005
Total Cost
$626,881
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Wigglesworth, Karen; Lee, Kyung-Bon; Emori, Chihiro et al. (2015) Transcriptomic diversification of developing cumulus and mural granulosa cells in mouse ovarian follicles. Biol Reprod 92:23
Lee, Kyung-Bon; Zhang, Meijia; Sugiura, Koji et al. (2013) Hormonal coordination of natriuretic peptide type C and natriuretic peptide receptor 3 expression in mouse granulosa cells. Biol Reprod 88:42
Zhang, Meijia; Su, You-Qiang; Sugiura, Koji et al. (2011) Estradiol promotes and maintains cumulus cell expression of natriuretic peptide receptor 2 (NPR2) and meiotic arrest in mouse oocytes in vitro. Endocrinology 152:4377-85
Zhang, Meijia; Su, You-Qiang; Sugiura, Koji et al. (2010) Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes. Science 330:366-9
Sugiura, Koji; Su, You-Qiang; Li, Qinglei et al. (2010) Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15. Mol Endocrinol 24:2303-14
Su, You-Qiang; Sugiura, Koji; Li, Qinglei et al. (2010) Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling. Mol Endocrinol 24:1230-9
Su, You-Qiang; Sugiura, Koji; Eppig, John J (2009) Mouse oocyte control of granulosa cell development and function: paracrine regulation of cumulus cell metabolism. Semin Reprod Med 27:32-42
Eppig, J J; O'Brien, M J; Wigglesworth, K et al. (2009) Effect of in vitro maturation of mouse oocytes on the health and lifespan of adult offspring. Hum Reprod 24:922-8
Sugiura, Koji; Su, You-Qiang; Eppig, John J (2009) Targeted suppression of Has2 mRNA in mouse cumulus cell-oocyte complexes by adenovirus-mediated short-hairpin RNA expression. Mol Reprod Dev 76:537-47
Su, You-Qiang; Sugiura, Koji; Woo, Yong et al. (2007) Selective degradation of transcripts during meiotic maturation of mouse oocytes. Dev Biol 302:104-17