Treatment studies have shown pre to post changes in reading circuits with evidence based remediation of reading disability, establishing the neural signature of successful treatment outcome. However, insight into the neurobiological mechanisms by which treatment produces these consequences/outcome requires monitoring modulations of key brain regions throughout the course of treatment and such data are lacking. Moreover, in any cohort some RD children with highly similar profiles on standardized testing at the beginning of intervention will show large gains and others will not. In the current proposal children with reading difficulties will be followed through an evidence-based training program focused on learning print-sound relationships with progressive emphasis at three grain sizes (grapheme-to-phoneme (GP), body/rime, and morphological) and the school-based small group instruction will be supplemented by online practice to reinforce training with an evidence-based computer assisted reading instruction (CARI). Cognitive testing and functional neuroimaging (before and after the intervention) with comparisons to untreated RD and TD control groups will allow for the identification of key neurocognitive factors associated with response to treatment. Eight recordings of brain activity using functional Near-Infrared Spectroscopy (fNIRS) imaging throughout the 20 weeks of instruction will be used to identify how online modulation of circuits during treatment relates to weekly measures of reading performance - growth spurts (or regressions) over the course of treatment. This dynamic tracking study will yield new insights into how evidence-based training modulates brain organization for learning to support reading gains and why it fails to do so for some children.
Specific Aims are: 1) To examine the pre to post training changes in print and speech activation and functional connectivity in relation to variable treatment responses. 2) To track dynamic adaptive changes in activation and functional connectivity during treatment that predict local growth spurts and outcomes in RD.
Aim 3) To examine neurocognitive changes associated with training on progressively larger grain-size units during treatment (GP, body/rime, morphological) and how these patterns are qualified by individual differences in pre-treatment profiles.

Public Health Relevance

The proposed research examines the neurocognitive bases of treatment response to a well-established evidence-based treatment program. We use pre and post treatment neuroimaging and, for the first time, frequent neuroimaging during the course of treatment 1) to gain new insights into how evidence-based treatment modulates brain organization for literacy, language learning, and remediation; and 2) why it fails to do so for some children. The proposed research represents a key step towards the development of comprehensive and mechanistic models of the neural underpinnings of typical and atypical reading development.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HD090153-04
Application #
9981480
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Miller, Brett
Project Start
2017-09-11
Project End
2022-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Haskins Laboratories, Inc.
Department
Type
DUNS #
060010147
City
New Haven
State
CT
Country
United States
Zip Code
06511
Pinti, Paola; Tachtsidis, Ilias; Hamilton, Antonia et al. (2018) The present and future use of functional near-infrared spectroscopy (fNIRS) for cognitive neuroscience. Ann N Y Acad Sci :
Chyl, Katarzyna; Kossowski, Bartosz; D?bska, Agnieszka et al. (2018) Prereader to beginning reader: changes induced by reading acquisition in print and speech brain networks. J Child Psychol Psychiatry 59:76-87
Rojiani, Rahil; Zhang, Xian; Noah, Adam et al. (2018) Communication of emotion via drumming: dual-brain imaging with functional near-infrared spectroscopy. Soc Cogn Affect Neurosci 13:1047-1057
Del Tufo, Stephanie N; Frost, Stephen J; Hoeft, Fumiko et al. (2018) Neurochemistry Predicts Convergence of Written and Spoken Language: A Proton Magnetic Resonance Spectroscopy Study of Cross-Modal Language Integration. Front Psychol 9:1507
Malins, Jeffrey G; Pugh, Kenneth R; Buis, Bonnie et al. (2018) Individual Differences in Reading Skill Are Related to Trial-by-Trial Neural Activation Variability in the Reading Network. J Neurosci 38:2981-2989
Landi, Nicole; Malins, Jeffrey G; Frost, Stephen J et al. (2018) Neural representations for newly learned words are modulated by overnight consolidation, reading skill, and age. Neuropsychologia 111:133-144
Dravida, Swethasri; Noah, Jack Adam; Zhang, Xian et al. (2018) Comparison of oxyhemoglobin and deoxyhemoglobin signal reliability with and without global mean removal for digit manipulation motor tasks. Neurophotonics 5:011006
Zhang, Xian; Noah, Jack Adam; Dravida, Swethasri et al. (2017) Signal processing of functional NIRS data acquired during overt speaking. Neurophotonics 4:041409