Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL005806-36
Application #
2211840
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
36
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pharmacology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Friedrichs, G S; Chi, L; Black, S C et al. (1994) Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart. J Cardiovasc Pharmacol 23:120-6
Chi, L; Friedrichs, G S; Oh, J Y et al. (1994) Effect of Ado A1- and A2-receptor activation on ventricular fibrillation during hypoxia-reoxygenation. Am J Physiol 267:H1447-54
Friedrichs, G S; Chi, L; Green, A L et al. (1994) Antifibrillatory effects of clofilium in the rabbit isolated heart. Br J Pharmacol 113:209-15
Black, S C; Butterfield, J L; Lucchesi, B R (1993) Protection against programmed electrical stimulation-induced ventricular tachycardia and sudden cardiac death by NE-10064, a class III antiarrhythmic drug. J Cardiovasc Pharmacol 22:810-8
Chi, L; Black, S C; Kuo, P I et al. (1993) Actions of pinacidil at a reduced potassium concentration: a direct cardiac effect possibly involving the ATP-dependent potassium channel. J Cardiovasc Pharmacol 21:179-90
Black, S C; Fagbemi, S O; Chi, L et al. (1993) Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide. J Mol Cell Cardiol 25:1427-38
Lucchesi, B R; Chi, L; Friedrichs, G S et al. (1993) Antiarrhythmic versus antifibrillatory actions: inference from experimental studies. Am J Cardiol 72:25F-44F
Fagbemi, S O; Chi, L; Lucchesi, B R (1993) Antifibrillatory and profibrillatory actions of selected class I antiarrhythmic agents. J Cardiovasc Pharmacol 21:709-19
Friedrichs, G S; Chi, L; Black, S C et al. (1993) Antifibrillatory effects of ibutilide in the rabbit isolated heart: mediation via ATP-dependent potassium channels. J Pharmacol Exp Ther 266:1348-54
Chi, L G; Mu, D X; Lucchesi, B R (1991) Electrophysiology and antiarrhythmic actions of E-4031 in the experimental animal model of sudden coronary death. J Cardiovasc Pharmacol 17:285-95

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