Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL013339-25
Application #
2214733
Study Section
Special Emphasis Panel (NSS)
Project Start
1979-04-01
Project End
1997-01-16
Budget Start
1995-04-01
Budget End
1997-01-16
Support Year
25
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Connecticut
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Farmington
State
CT
Country
United States
Zip Code
06030

  Publications

Shen, Jian-Bing; Pappano, Achilles J (2008) An estrogen metabolite, 2-methoxyestradiol, disrupts cardiac microtubules and unmasks muscarinic inhibition of calcium current. J Pharmacol Exp Ther 325:507-12
Gomez, Ana M; Kerfant, Benoit-Gilles; Vassort, Guy et al. (2004) Autonomic regulation of calcium and potassium channels is oppositely modulated by microtubules in cardiac myocytes. Am J Physiol Heart Circ Physiol 286:H2065-71
Shen, Jian-Bing; Pappano, Achilles J (2002) On the role of phosphatase in regulation of cardiac L-type calcium current by cyclic GMP. J Pharmacol Exp Ther 301:501-6
Imai, Y; Jiang, B; Pappano, A J (2001) Mechanism for muscarinic inhibition of I(Ca(L)) is determined by the path for elevating cyclic AMP in cardiac myocytes. Cardiovasc Res 51:331-43
Shen, J B; Pappano, A J (2001) Carbachol inhibits the L-type Ca2+ current augmented by 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid in guinea pig ventricular myocytes: calcium-sensitivity hypothesis for muscarinic inhibition. J Pharmacol Exp Ther 298:857-64
Shen, J B; Jiang, B; Pappano, A J (2000) Comparison of L-type calcium channel blockade by nifedipine and/or cadmium in guinea pig ventricular myocytes. J Pharmacol Exp Ther 294:562-70
Sakai, R; Shen, J B; Pappano, A J (1999) Elevated cAMP suppresses muscarinic inhibition of L-type calcium current in guinea pig ventricular myocytes. J Cardiovasc Pharmacol 34:304-15
Saeki, T; Shen, J B; Pappano, A J (1999) Inositol-1,4,5-trisphosphate increases contractions but not L-type calcium current in guinea pig ventricular myocytes. Cardiovasc Res 41:620-8
Shen, J B; Jiang, B; Pappano, A J (1999) Lack of effect of McN-A-343 on membrane current and contraction in guinea pig ventricular myocytes. J Pharmacol Exp Ther 290:641-8
Protas, L; Shen, J B; Pappano, A J (1998) Carbachol increases contractions and intracellular Ca++ transients in guinea pig ventricular myocytes. J Pharmacol Exp Ther 284:66-74

Showing the most recent 10 out of 40 publications