Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37HL013629-20
Application #
3485375
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1970-06-01
Project End
1994-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
20
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Bloodcenter of Wisconsin, Inc.
Department
Type
DUNS #
City
Milwaukee
State
WI
Country
United States
Zip Code
53233
Curtis, Brian R; Hsu, Yen-Michael S; Podoltsev, Nikolai et al. (2018) Patients treated with oxaliplatin are at risk for thrombocytopenia caused by multiple drug-dependent antibodies. Blood 131:1486-1489
Jones, Curtis G; Pechauer, Shannon M; Curtis, Brian R et al. (2017) A Platelet Factor 4-Dependent Platelet Activation Assay Facilitates Early Detection of Pathogenic Heparin-Induced Thrombocytopenia Antibodies. Chest 152:e77-e80
Padmanabhan, Anand; Jones, Curtis G; Pechauer, Shannon M et al. (2017) IVIg for Treatment of Severe Refractory Heparin-Induced Thrombocytopenia. Chest 152:478-485
Padmanabhan, Anand; Jones, Curtis G; Curtis, Brian R et al. (2016) A Novel PF4-Dependent Platelet Activation Assay Identifies Patients Likely to Have Heparin-Induced Thrombocytopenia/Thrombosis. Chest 150:506-15
Bougie, Daniel W; Peterson, Julie; Rasmussen, Mark et al. (2015) Mechanism of quinine-dependent monoclonal antibody binding to platelet glycoprotein IIb/IIIa. Blood 126:2146-52
Padmanabhan, Anand; Jones, Curtis G; Bougie, Daniel W et al. (2015) Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis. Blood 125:155-61
Padmanabhan, Anand; Jones, Curtis G; Bougie, Daniel W et al. (2015) A modified PF4-dependent, CD62p expression assay selectively detects serotonin-releasing antibodies in patients suspected of HIT. Thromb Haemost 114:1322-3
Zhu, Jianghai; Zhu, Jieqing; Bougie, Daniel W et al. (2015) Structural basis for quinine-dependent antibody binding to platelet integrin ?IIb?3. Blood 126:2138-45
Jiang, Jian-kang; McCoy, Joshua G; Shen, Min et al. (2014) A novel class of ion displacement ligands as antagonists of the ?IIb?3 receptor that limit conformational reorganization of the receptor. Bioorg Med Chem Lett 24:1148-53
Bougie, Daniel W; Peterson, Julie A; Kanack, Adam J et al. (2014) Transfusion-related acute lung injury-associated HNA-3a antibodies recognize complex determinants on choline transporter-like protein 2. Transfusion 54:3208-15

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