This program is designed to provide a multifaceted approach to the study of the physiological significance of in vitro blood rheology studies. The long range goal of the proposed research is to contribute to the understanding of the relation of the rheological properties of blood to: 1) the flow of blood in vivo; 2) the diagnosis and treatment of clinical disorders associated with potential rheological alterations.
The specific aims of the present program include: 1) studies of the flow behavior of various erythrocyte suspensions in narrow bore glass tubes having geometries relevant to the microcirculation; 2) physical- hemorheological analyses of the effects of liquid storage of human blood intended for transfusion, including macro- and micro- rheologic studies and the evaluation of potassium-containing storage media; 3) continue studies of specific erythrocyte cellular factors which influence erythrocyte aggregation and thus to explore possible reasons for differences in aggregation noted between young and old red cells and between red cells from normal donors; 4) hemorheological evaluation of blood, red cells and white cells from patients whose clinical state is characterized by altered rheological properties of blood (i.e., acute cerebral ischemia, diabetes mellitus, acute myocardial infarction). Successful completion of the major aims of this program should provide: 1) quantitative information relevant to the prediction of pressure- flow relations in a vascular bed based on in vitro rheologic data; 2) additional insight into the mechanisms involved in red cell aggregation; 3) detailed data regarding the macro- and micro- rheological properties of stored and pathologic blood. Of long range significance is the potential contribution which studies of this type may make to clinical medicine: if syndromes of """"""""hyperviscosity"""""""" are to be utilized with scientific meaning, a clearer understanding of their etiology, rheologic mechanisms and physiological import is essential.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37HL015722-22
Application #
2214899
Study Section
Special Emphasis Panel (NSS)
Project Start
1979-05-01
Project End
1999-04-30
Budget Start
1994-05-06
Budget End
1995-04-30
Support Year
22
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Southern California
Department
Physiology
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Alexy, Tamas; Pais, Eszter; Wenby, Rosalinda B et al. (2015) Abnormal blood rheology and chronic low grade inflammation: possible risk factors for accelerated atherosclerosis and coronary artery disease in Lewis negative subjects. Atherosclerosis 239:248-51
Sonmez, Melda; Ince, Huseyin Yavuz; Yalcin, Ozlem et al. (2013) The effect of alcohols on red blood cell mechanical properties and membrane fluidity depends on their molecular size. PLoS One 8:e76579
Meram, Ece; Yilmaz, Bahar D; Bas, Ceren et al. (2013) Shear stress-induced improvement of red blood cell deformability. Biorheology 50:165-76
Baskurt, Oguz K; Meiselman, Herbert J (2013) Red blood cell mechanical stability test. Clin Hemorheol Microcirc 55:55-62
Ulker, Pinar; Gunduz, Filiz; Meiselman, Herbert J et al. (2013) Nitric oxide generated by red blood cells following exposure to shear stress dilates isolated small mesenteric arteries under hypoxic conditions. Clin Hemorheol Microcirc 54:357-69
Rabai, Miklos; Meiselman, Herbert J; Wenby, Rosalinda B et al. (2012) Analysis of light scattering by red blood cells in ektacytometry using global pattern fitting. Biorheology 49:317-28
Ulker, Pinar; Yaras, Nazmi; Yalcin, Ozlem et al. (2011) Shear stress activation of nitric oxide synthase and increased nitric oxide levels in human red blood cells. Nitric Oxide 24:184-91
Alexy, Tamas; Baskurt, Oguz K; Nemeth, Norbert et al. (2011) Effect of lanthanides on red blood cell deformability and response to mechanical stress: role of lanthanide ionic radius. Biorheology 48:173-83
Gündüz, F; Koçer, G; Ulker, S et al. (2011) Exercise training enhances flow-mediated dilation in spontaneously hypertensive rats. Physiol Res 60:589-97
Uyuklu, Mehmet; Canpolat, Murat; Meiselman, Herbert J et al. (2011) Wavelength selection in measuring red blood cell aggregation based on light transmittance. J Biomed Opt 16:117006

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