Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL016634-31
Application #
2215001
Study Section
Special Emphasis Panel (NSS)
Project Start
1979-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
31
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Zhang, Chunfen; Majerus, Philip W; Wilson, Monita P (2012) Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation. Proc Natl Acad Sci U S A 109:2290-5
Zou, Jun; Zhang, Chunfen; Marjanovic, Jasna et al. (2012) Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. Proc Natl Acad Sci U S A 109:9539-44
Zou, Jun; Majerus, Philip W; Wilson, David B et al. (2012) The role of myotubularin-related phosphatases in the control of autophagy and programmed cell death. Adv Biol Regul 52:282-9
Ferron, Mathieu; Boudiffa, Maya; Arsenault, Michel et al. (2011) Inositol polyphosphate 4-phosphatase B as a regulator of bone mass in mice and humans. Cell Metab 14:466-77
Marjanovic, Jasna; Wilson, Monita P; Zhang, Chunfen et al. (2011) The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model. Adv Enzyme Regul 51:101-5
Traynor-Kaplan, Alexis E; Moody, Mark; Nur, Magda et al. (2010) INO-4995 therapeutic efficacy is enhanced with repeat dosing in cystic fibrosis knockout mice and human epithelia. Am J Respir Cell Mol Biol 42:105-12
Majerus, Philip W; Wilson, David B; Zhang, Chunfen et al. (2010) Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects. Adv Enzyme Regul 50:365-72
Wilson, Monita P; Hugge, Christopher; Bielinska, Malgorzata et al. (2009) Neural tube defects in mice with reduced levels of inositol 1,3,4-trisphosphate 5/6-kinase. Proc Natl Acad Sci U S A 106:9831-5
Vomund, Anthony N; Majerus, Elaine M (2009) ADAMTS13 bound to endothelial cells exhibits enhanced cleavage of von Willebrand factor. J Biol Chem 284:30925-32
Jacoby, Monique; Cox, James J; Gayral, Stéphanie et al. (2009) INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nat Genet 41:1027-31

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