Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL017818-23
Application #
2215080
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-12-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Newark
State
NJ
Country
United States
Zip Code
07107
Honda, A; Salen, G; Matsuzaki, Y et al. (2001) Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX. J Lipid Res 42:291-300
Honda, M; Tint, G S; Honda, A et al. (2000) Regulation of cholesterol biosynthetic pathway in patients with the Smith-Lemli-Opitz syndrome. J Inherit Metab Dis 23:464-74
Xu, G; Shneider, B L; Shefer, S et al. (2000) Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits. J Lipid Res 41:298-304
Honda, A; Salen, G; Shefer, S et al. (2000) Regulation of 25- and 27-hydroxylation side chain cleavage pathways for cholic acid biosynthesis in humans, rabbits, and mice. Assay of enzyme activities by high-resolution gas chromatography;-mass spectrometry. J Lipid Res 41:442-51
Honda, A; Salen, G; Honda, M et al. (2000) 3-Hydroxy-3-methylglutaryl-coenzyme A reductase activity is inhibited by cholesterol and up-regulated by sitosterol in sitosterolemic fibroblasts. J Lab Clin Med 135:174-9
Xu, G; Salen, G; Shefer, S et al. (1999) Increasing dietary cholesterol induces different regulation of classic and alternative bile acid synthesis. J Clin Invest 103:89-95
Batta, A K; Datta, S C; Tint, G S et al. (1999) A convenient synthesis of dinorbile acids: oxidative hydrolysis of norbile acid nitriles. Steroids 64:780-4
Honda, A; Salen, G; Shefer, S et al. (1999) Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7alpha-hydroxylase and 27-hydroxylase activities in rat liver. J Lipid Res 40:1520-8
Ertel, N H; Dayal, B; Rao, K et al. (1999) Anomalous enantioselectivity in the sharpless asymmetric dihydroxylation reaction of 24-nor-5beta-cholest-23-ene-3alpha,7alpha,12alpha-triol: synthesis of substrates for studies of cholesterol side-chain oxidation. Lipids 34:395-405
Batta, A K; Salen, G; Rapole, K R et al. (1999) Highly simplified method for gas-liquid chromatographic quantitation of bile acids and sterols in human stool. J Lipid Res 40:1148-54

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