Abstract

The proposed research will continue to elucidate the multiple factors which control myocardial perfusion. As in the past, the aim of this work is to answer questions important in defining the physiology and pathophysiology of coronary blood flow in animal models which are closely akin to man in a physiologic state. Thus, this work will be carried out in awake animal models. The research proposal contains two specific aims: 1) beat-to-beat regulation of coronary blood flow, and 2) physical, pharmacologic and neural factors which affect atrial blood flow.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL018468-12
Application #
3485562
Study Section
Cardiovascular Study Section (CVA)
Project Start
1976-05-01
Project End
1991-04-30
Budget Start
1987-05-01
Budget End
1988-04-30
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Ishibashi, Y; Rembert, J C; Carabello, B A et al. (2001) Normal myocardial function in severe right ventricular volume overload hypertrophy. Am J Physiol Heart Circ Physiol 280:H11-6
Dolber, P C; Bauman, R P; Rembert, J C et al. (1998) Are interatrial band myocytes maximally hypertrophied in normal canine hearts? Am J Physiol 275:H1225-35
Milano, C A; Allen, L F; Dolber, P C et al. (1995) Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. J Thorac Cardiovasc Surg 109:236-41
Milano, C A; Dolber, P C; Rockman, H A et al. (1994) Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy. Proc Natl Acad Sci U S A 91:10109-13
Milano, C A; Allen, L F; Rockman, H A et al. (1994) Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science 264:582-6
Dolber, P C; Bauman, R P; Rembert, J C et al. (1994) Regional changes in myocyte structure in model of canine right atrial hypertrophy. Am J Physiol 267:H1279-87
Bauman, R P; Rembert, J C; Greenfield Jr, J C (1993) Regional blood flow in canine atria during exercise. Am J Physiol 265:H629-32
Dolber, P C; Spach, M S (1993) Conventional and confocal fluorescence microscopy of collagen fibers in the heart. J Histochem Cytochem 41:465-9
Parsons, W J; Rembert, J C; Bauman, R P et al. (1993) Myocardial oxygenation in dogs during partial and complete coronary artery occlusion. Circ Res 73:458-64
Dolber, P C; Beyer, E C; Junker, J L et al. (1992) Distribution of gap junctions in dog and rat ventricle studied with a double-label technique. J Mol Cell Cardiol 24:1443-57

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