Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL019278-21
Application #
2027999
Study Section
Special Emphasis Panel (NSS)
Project Start
1976-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Buitrago, Lorena; Rendon, Augusto; Liang, Yupu et al. (2015) ?IIb?3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia. Proc Natl Acad Sci U S A 112:E1898-907
Coller, Barry S (2015) Blood at 70: its roots in the history of hematology and its birth. Blood 126:2548-60
Coller, B S (2015) ?IIb?3: structure and function. J Thromb Haemost 13 Suppl 1:S17-25
Jiang, Jian-kang; McCoy, Joshua G; Shen, Min et al. (2014) A novel class of ion displacement ligands as antagonists of the ?IIb?3 receptor that limit conformational reorganization of the receptor. Bioorg Med Chem Lett 24:1148-53
Provasi, Davide; Negri, Ana; Coller, Barry S et al. (2014) Talin-driven inside-out activation mechanism of platelet ?IIb?3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations. Proteins 82:3231-3240
Wang, Wei; Vootukuri, Spandana; Meyer, Alexander et al. (2014) Association between shear stress and platelet-derived transforming growth factor-?1 release and activation in animal models of aortic valve stenosis. Arterioscler Thromb Vasc Biol 34:1924-32
Coller, Barry S (2014) The platelet: life on the razor's edge between hemorrhage and thrombosis. Transfusion 54:2137-46
Choi, Won-Seok; Rice, William J; Stokes, David L et al. (2013) Three-dimensional reconstruction of intact human integrin ?IIb?3: new implications for activation-dependent ligand binding. Blood 122:4165-71
Brophy, Teresa M; Coller, Barry S; Ahamed, Jasimuddin (2013) Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor ?1 (TGF-?1) activation. J Biol Chem 288:10628-39
Fuster, Valentin; Bhatt, Deepak L; Califf, Robert M et al. (2012) Guided antithrombotic therapy: current status and future research direction: report on a National Heart, Lung and Blood Institute working group. Circulation 126:1645-62

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