Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL019429-21
Application #
2215277
Study Section
Special Emphasis Panel (NSS)
Project Start
1979-06-01
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Yang, Zhiping; Chiou, Terry Ting-Yu; Stossel, Thomas P et al. (2015) Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function. Am J Physiol Lung Cell Mol Physiol 309:L11-6
Nakamura, Fumihiko; Stossel, Thomas P; Hartwig, John H (2011) The filamins: organizers of cell structure and function. Cell Adh Migr 5:160-9
Kasza, K E; Broedersz, C P; Koenderink, G H et al. (2010) Actin filament length tunes elasticity of flexibly cross-linked actin networks. Biophys J 99:1091-100
Kasza, K E; Nakamura, F; Hu, S et al. (2009) Filamin A is essential for active cell stiffening but not passive stiffening under external force. Biophys J 96:4326-35
Koenderink, Gijsje H; Dogic, Zvonimir; Nakamura, Fumihiko et al. (2009) An active biopolymer network controlled by molecular motors. Proc Natl Acad Sci U S A 106:15192-7
Nakamura, Fumihiko; Heikkinen, Outi; Pentikainen, Olli T et al. (2009) Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations. PLoS One 4:e4928
Nakamura, Fumihiko; Osborn, Teresia M; Hartemink, Christopher A et al. (2007) Structural basis of filamin A functions. J Cell Biol 179:1011-25
Weins, Astrid; Schlondorff, Johannes S; Nakamura, Fumihiko et al. (2007) Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A 104:16080-5
Gardel, M L; Nakamura, F; Hartwig, J H et al. (2006) Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc Natl Acad Sci U S A 103:1762-7
Gardel, M L; Nakamura, F; Hartwig, J et al. (2006) Stress-dependent elasticity of composite actin networks as a model for cell behavior. Phys Rev Lett 96:088102

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