Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL021195-20
Application #
2215444
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Emory University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Kuruma, A; Hirayama, Y; Hartzell, H C (2000) A hyperpolarization- and acid-activated nonselective cation current in Xenopus oocytes. Am J Physiol Cell Physiol 279:C1401-13
Kuruma, A; Hartzell, H C (1999) Dynamics of calcium regulation of chloride currents in Xenopus oocytes. Am J Physiol 276:C161-75
Machaca, K; HC Hartzell (1999) Reversible Ca gradients between the subplasmalemma and cytosol differentially activate Ca-dependent Cl currents. J Gen Physiol 113:249-66
Machaca, K; Hartzell, H C (1999) Adenophostin A and inositol 1,4,5-trisphosphate differentially activate Cl- currents in Xenopus oocytes because of disparate Ca2+ release kinetics. J Biol Chem 274:4824-31
Hirayama, Y; Hartzell, H C (1997) Effects of protein phosphatase and kinase inhibitors on Ca2+ and Cl- currents in guinea pig ventricular myocytes. Mol Pharmacol 52:725-34
Hartzell, H C; Rinderknecht, A (1996) Calphostin C, a widely used protein kinase C inhibitor, directly and potently blocks L-type Ca channels. Am J Physiol 270:C1293-9
Hartzell, H C; Hirayama, Y; Petit-Jacques, J (1995) Effects of protein phosphatase and kinase inhibitors on the cardiac L-type Ca current suggest two sites are phosphorylated by protein kinase A and another protein kinase. J Gen Physiol 106:393-414
Frace, A M; Hartzell, H C (1993) Opposite effects of phosphatase inhibitors on L-type calcium and delayed rectifier currents in frog cardiac myocytes. J Physiol 472:305-26
Mery, P F; Frace, A M; Hartzell, H C et al. (1993) A comparative analysis of the time course of cardiac Ca2+ current response to rapid applications of beta-adrenergic and dihydropyridine agonists. Naunyn Schmiedebergs Arch Pharmacol 348:197-206
Parsons, T D; Hartzell, H C (1993) Regulation of Ca2+ current in frog ventricular cardiomyocytes by guanosine 5'-triphosphate analogues and isoproterenol. J Gen Physiol 102:525-49

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