Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL022231-28
Application #
6979810
Study Section
Special Emphasis Panel (NSS)
Program Officer
Przywara, Dennis
Project Start
1988-04-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
28
Fiscal Year
2006
Total Cost
$333,029
Indirect Cost
Name
University of Illinois at Chicago
Department
Physiology
Type
Schools of Medicine
DUNS #
098987217
City
Chicago
State
IL
Country
United States
Zip Code
60612
Puglisi, Jose L; Goldspink, Paul H; Gomes, Aldrin V et al. (2014) Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys 552-553:50-9
Nixon, Benjamin R; Liu, Bin; Scellini, Beatrice et al. (2013) Tropomyosin Ser-283 pseudo-phosphorylation slows myofibril relaxation. Arch Biochem Biophys 535:30-8
Lovelock, Joshua D; Monasky, Michelle M; Jeong, Euy-Myoung et al. (2012) Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res 110:841-50
Sheehan, Katherine A; Arteaga, Grace M; Hinken, Aaron C et al. (2011) Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis. J Mol Cell Cardiol 50:442-50
Karam, Chehade N; Warren, Chad M; Rajan, Sudarsan et al. (2011) Expression of tropomyosin-ýý induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross-bridge dependent activation and altered tropomyosin phosphorylation. J Muscle Res Cell Motil 31:315-22
Solaro, R John; Kobayashi, Tomoyoshi (2011) Protein phosphorylation and signal transduction in cardiac thin filaments. J Biol Chem 286:9935-40
Peña, James R; Szkudlarek, Ariani C; Warren, Chad M et al. (2010) Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol 49:993-1002
Rajan, Sudarsan; Jagatheesan, Ganapathy; Karam, Chehade N et al. (2010) Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation 121:410-8
Biesiadecki, Brandon J; Tachampa, Kittipong; Yuan, Chao et al. (2010) Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice. J Biol Chem 285:19688-98
Jagatheesan, Ganapathy; Rajan, Sudarsan; Ahmed, Rafeeq P H et al. (2010) Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity. J Muscle Res Cell Motil 31:227-39

Showing the most recent 10 out of 99 publications