Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL026284-16
Application #
2215978
Study Section
Special Emphasis Panel (NSS)
Project Start
1980-09-01
Project End
1997-03-31
Budget Start
1995-09-01
Budget End
1997-03-31
Support Year
16
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Biochemistry
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Stewart, John M; Gera, Lajos; Chan, Daniel C et al. (2005) Combination cancer chemotherapy with one compound: pluripotent bradykinin antagonists. Peptides 26:1288-91
Stewart, John M; Gera, Lajos; Chan, Daniel C et al. (2004) New lung cancer drugs from bradykinin antagonists. Chest 125:148S
Schroeder, Christian; Breit, Andreas; Boning, Hilke et al. (2003) Changes in amino-terminal portion of human B2 receptor selectively increase efficacy of synthetic ligand HOE 140 but not of cognate ligand bradykinin. Am J Physiol Heart Circ Physiol 284:H1924-32
Stewart, J M (2003) Bradykinin antagonists as anti-cancer agents. Curr Pharm Des 9:2036-42
Stewart, John M; Gera, Lajos; Chan, Daniel C et al. (2002) Bradykinin-related compounds as new drugs for cancer and inflammation. Can J Physiol Pharmacol 80:275-80
Taraseviciene-Stewart, Laimute; Gera, Lajos; Hirth, Peter et al. (2002) A bradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model. Can J Physiol Pharmacol 80:269-74
Stewart, J M; Gera, L; York, E J et al. (2001) Metabolism-resistant bradykinin antagonists: development and applications. Biol Chem 382:37-41
Reissmann, S; Pineda, F; Vietinghoff, G et al. (2000) Structure activity relationships for bradykinin antagonists on the inhibition of cytokine release and the release of histamine. Peptides 21:527-33
Larrivee, J F; Gera, L; Houle, S et al. (2000) Non-competitive pharmacological antagonism at the rabbit B(1) receptor. Br J Pharmacol 131:885-92
Stewart, J M; Gera, L; York, E J et al. (1999) Bradykinin antagonists: present progress and future prospects. Immunopharmacology 43:155-61

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