Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL030647-14
Application #
2216682
Study Section
Special Emphasis Panel (NSS)
Project Start
1983-01-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1998-03-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Hawiger, J; Veach, R A; Liu, X Y et al. (1999) IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells. Blood 94:1711-6
Torgerson, T R; Colosia, A D; Donahue, J P et al. (1998) Regulation of NF-kappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-kappa B p50. J Immunol 161:6084-92
Zhang, L; Torgerson, T R; Liu, X Y et al. (1998) Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules. Proc Natl Acad Sci U S A 95:9184-9
Hawiger, J (1997) Cellular import of functional peptides to block intracellular signaling. Curr Opin Immunol 9:189-94
Liu, K Y; Timmons, S; Lin, Y Z et al. (1996) Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs. Proc Natl Acad Sci U S A 93:11819-24
Lin, Y Z; Yao, S Y; Hawiger, J (1996) Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways. J Biol Chem 271:5305-8
Hawiger, J (1995) Mechanisms involved in platelet vessel wall interaction. Thromb Haemost 74:369-72
Donald, R; Ballard, D W; Hawiger, J (1995) Proteolytic processing of NF-kappa B/I kappa B in human monocytes. ATP-dependent induction by pro-inflammatory mediators. J Biol Chem 270:9-12
Donahue, J P; Patel, H; Anderson, W F et al. (1994) Three-dimensional structure of the platelet integrin recognition segment of the fibrinogen gamma chain obtained by carrier protein-driven crystallization. Proc Natl Acad Sci U S A 91:12178-82
Cordle, S R; Donald, R; Read, M A et al. (1993) Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells. J Biol Chem 268:11803-10

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