Although various physiological and biochemical functions have been studied in fetal and in neonatal mammals, the role of the individual components of the birth process in inducing the changes which occur after birth, have not been well delineated. In this project, it is planned to examine the role of some of the events which occur at birth on circulatory, metabolic, and hormonal adjustments. The studies will be conducted in chronically-instrumented fetal lambs, in utero, and various perinatal events will be simulated. These include the effects of: 1) pulmonary ventilation in utero, with no change in blood gases, 2) ventilation with air or oxygen to increase arterial saturation to postnatal levels, 3) umbilical cord occlusion, 4) body cooling without stimulating cutaneous receptors, 5) surface cooling, and 6) combination of ventilation, oxygenation, and cooling. The effects of these events on the following will be studied: a) general circulatory responses including heart rate, intracardiac flows and cardiac output and its distribution, b) hormonal responses, particularly of catecholamines and thyroid hormones, c) metabolism of carbohydrate and fatty acids, d) myocardial blood flow and metabolism, and g) gastrointestinal blood flow and metabolism.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL035842-02
Application #
3486086
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1986-01-01
Project End
1990-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Rudolph, A M; Roman, C; Gournay, V (1999) Perinatal myocardial DNA and protein changes in the lamb: effect of cortisol in the fetus. Pediatr Res 46:141-6
van Bel, F; Sola, A; Roman, C et al. (1997) Perinatal regulation of the cerebral circulation: role of nitric oxide and prostaglandins. Pediatr Res 42:299-304
Berning, R A; Klautz, R J; Teitel, D F (1997) Perinatal left ventricular performance in fetal sheep: interaction between oxygen ventilation and contractility. Pediatr Res 41:57-64
van Bel, F; Sola, A; Roman, C et al. (1995) Role of nitric oxide in the regulation of the cerebral circulation in the lamb fetus during normoxemia and hypoxemia. Biol Neonate 68:200-10
Boekkooi, P F; Baan Jr, J; Teitel, D F et al. (1995) Effect of drugs on chemoreceptor responsiveness in fetal sheep. Pediatr Res 38:938-43
Van Bel, F; Bartelds, B; Teitel, D F et al. (1995) Effect of indomethacin on cerebral blood flow and oxygenation in the normal and ventilated fetal lamb. Pediatr Res 38:243-50
van Bel, F; Roman, C; Klautz, R J et al. (1994) Relationship between brain blood flow and carotid arterial flow in the sheep fetus. Pediatr Res 35:329-33
Baan Jr, J; Boekkooi, P F; Teitel, D F et al. (1993) Heart rate fall during acute hypoxemia: a measure of chemoreceptor response in fetal sheep. J Dev Physiol 19:105-11
van Bel, F; Roman, C; Iwamoto, H S et al. (1993) Sympathoadrenal, metabolic, and regional blood flow responses to cold in fetal sheep. Pediatr Res 34:47-50
Iwamoto, H S; Teitel, D F; Rudolph, A M (1993) Effects of lung distension and spontaneous fetal breathing on hemodynamics in sheep. Pediatr Res 33:639-44

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