Cell Mutants Defective in Cholesterol Ester Formation

Chang, Ta-Yuan

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 2R37HL036709-09
• Application #: 2218254
• Study Section: Metabolism Study Section (MET)
• Project Start: 1989-07-01
• Project End: 1999-05-31
• Budget Start: 1994-07-01
• Budget End: 1995-05-31
• Support Year: 9
• Fiscal Year: 1994

Institution

• Name: Dartmouth College
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 041027822
• City: Hanover
• State: NH
• Country: United States
• Zip Code: 03755

Publications

Poirier, Steve; Mayer, Gaétan; Murphy, Stephanie R et al. (2013) The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins. Traffic 14:458-69

Lu, Ming; Hu, Xi-Han; Li, Qin et al. (2013) A specific cholesterol metabolic pathway is established in a subset of HCCs for tumor growth. J Mol Cell Biol 5:404-15

Sakashita, Naomi; Chang, Catherine C Y; Lei, Xiaofeng et al. (2010) Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity. J Lipid Res 51:1263-72

Chen, Jia; Zhao, Xiao-Nan; Yang, Li et al. (2008) RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform. Cell Res 18:921-36

Urano, Yasuomi; Watanabe, Hiroshi; Murphy, Stephanie R et al. (2008) Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex. Proc Natl Acad Sci U S A 105:16513-8

Yamauchi, Yoshio; Reid, Patrick C; Sperry, Jeffrey B et al. (2007) Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols. J Biol Chem 282:34994-5004

Sugii, Shigeki; Lin, Song; Ohgami, Nobutaka et al. (2006) Roles of endogenously synthesized sterols in the endocytic pathway. J Biol Chem 281:23191-206

Yamauchi, Yoshio; Chang, Catherine C Y; Hayashi, Michi et al. (2004) Intracellular cholesterol mobilization involved in the ABCA1/apolipoprotein-mediated assembly of high density lipoprotein in fibroblasts. J Lipid Res 45:1943-51

Reid, Patrick C; Sakashita, Naomi; Sugii, Shigeki et al. (2004) A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain. J Lipid Res 45:582-91

Yang, Li; Yang, Jin Bo; Chen, Jia et al. (2004) Enhancement of human ACAT1 gene expression to promote the macrophage-derived foam cell formation by dexamethasone. Cell Res 14:315-23