Antibodies to IP3-Receptor/Channel in Human Platelets

Feinstein, Maurice B.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37HL037422-10
• Application #: 2218459
• Study Section: Special Emphasis Panel (NSS)
• Project Start: 1987-01-01
• Project End: 1997-12-31
• Budget Start: 1996-01-01
• Budget End: 1997-12-31
• Support Year: 10
• Fiscal Year: 1996

Institution

• Name: University of Connecticut
• Department: Pharmacology
• Type: Schools of Medicine
• City: Farmington
• State: CT
• Country: United States
• Zip Code: 06030

Publications

O'Rourke, F; Feinstein, M B (1990) The inositol 1,4,5-trisphosphate receptor binding sites of platelet membranes. pH-dependency, inhibition by polymeric sulphates, and the possible presence of arginine at the binding site. Biochem J 267:297-302

O'Rourke, F; Zavoico, G B; Feinstein, M B (1989) Release of Ca2+ by inositol 1,4,5-trisphosphate in platelet membrane vesicles is not dependent on cyclic AMP-dependent protein kinase. Biochem J 257:715-21

O'Rourke, F; Zavoico, G B; Smith Jr, L H et al. (1987) Stimulus-response coupling in a cell-free platelet membrane system. GTP-dependent release of Ca2+ by thrombin, and inhibition by pertussis toxin and a monoclonal antibody that blocks calcium release by IP3. FEBS Lett 214:176-80