Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL043671-07
Application #
2221124
Study Section
Special Emphasis Panel (NSS)
Project Start
1995-01-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Wang, Qin; Limbird, Lee E (2007) Regulation of alpha2AR trafficking and signaling by interacting proteins. Biochem Pharmacol 73:1135-45
Hu, Xinran; Friedman, David; Hill, Salisha et al. (2005) Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor. J Mol Endocrinol 35:73-88
Tan, Christopher M; Brady, Ashley E; Nickols, Hilary Highfield et al. (2004) Membrane trafficking of G protein-coupled receptors. Annu Rev Pharmacol Toxicol 44:559-609
Zhang, Y Q; Limbird, L E (2004) Hetero-oligomers of alpha2A-adrenergic and mu-opioid receptors do not lead to transactivation of G-proteins or altered endocytosis profiles. Biochem Soc Trans 32:856-60
Peng, Ning; Chambless, Brandon D; Oparil, Suzanne et al. (2003) Alpha2A-adrenergic receptors mediate sympathoinhibitory responses to atrial natriuretic peptide in the mouse anterior hypothalamic nucleus. Hypertension 41:571-5
Tan, Christopher M; Wilson, Matthew H; MacMillan, Leigh B et al. (2002) Heterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists. Proc Natl Acad Sci U S A 99:12471-6
Franowicz, Jenna S; Kessler, Lynn E; Borja, Catherine M Dailey et al. (2002) Mutation of the alpha2A-adrenoceptor impairs working memory performance and annuls cognitive enhancement by guanfacine. J Neurosci 22:8771-7
Bruban, Veronique; Estato, Vanessa; Schann, Stephan et al. (2002) Evidence for synergy between alpha(2)-adrenergic and nonadrenergic mechanisms in central blood pressure regulation. Circulation 105:1116-21
Bissonnette, J M; Knopp, S J; Wright, D M et al. (2001) Respiratory pattern and hypoxic ventilatory response in mice functionally lacking alpha2A-adrenergic receptors. Adv Exp Med Biol 499:201-8
Wilson, M H; Highfield, H A; Limbird, L E (2001) The role of a conserved inter-transmembrane domain interface in regulating alpha(2a)-adrenergic receptor conformational stability and cell-surface turnover. Mol Pharmacol 59:929-38

Showing the most recent 10 out of 24 publications