Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL044147-08
Application #
2221349
Study Section
Special Emphasis Panel (NSS)
Project Start
1989-05-01
Project End
1999-04-30
Budget Start
1996-05-15
Budget End
1997-04-30
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Chien, Shu (2003) Molecular and mechanical bases of focal lipid accumulation in arterial wall. Prog Biophys Mol Biol 83:131-51
Liu, Yi; Chen, Benjamin P-C; Lu, Min et al. (2002) Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol 22:76-81
Zhao, Y; Chien, S; Skalak, R et al. (2001) Leukocyte rolling in rat mesentery venules: distribution of adhesion bonds and the effects of cytoactive agents. Ann Biomed Eng 29:360-72
Shyy, J Y (2001) Mechanotransduction in endothelial responses to shear stress: review of work in Dr. Chien's laboratory. Biorheology 38:109-17
Jin, G; Chieh-Hsi Wu, J; Li, Y S et al. (2000) Effects of active and negative mutants of Ras on rat arterial neointima formation. J Surg Res 94:124-32
Jin, G; Sah, R L; Li, Y S et al. (2000) Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res 18:899-908
Chen, K D; Li, Y S; Kim, M et al. (1999) Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. J Biol Chem 274:18393-400
Artmann, G M; Kelemen, C; Porst, D et al. (1998) Temperature transitions of protein properties in human red blood cells. Biophys J 75:3179-83
Chien, S; Shyy, J Y (1998) Effects of hemodynamic forces on gene expression and signal transduction in endothelial cells. Biol Bull 194:390-1;discussion 392-3
Chien, S; Li, S; Shyy, Y J (1998) Effects of mechanical forces on signal transduction and gene expression in endothelial cells. Hypertension 31:162-9

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