Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL050022-13
Application #
6877695
Study Section
Special Emphasis Panel (NSS)
Program Officer
Berberich, Mary Anne
Project Start
1993-04-01
Project End
2008-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
13
Fiscal Year
2005
Total Cost
$425,428
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Maitra, Meenakshi; Wang, Yongyu; Gerard, Robert D et al. (2010) Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress. J Biol Chem 285:22103-13
Mendelson, Carole R (2009) Minireview: fetal-maternal hormonal signaling in pregnancy and labor. Mol Endocrinol 23:947-54
Liu, Dongyuan; Benlhabib, Houda; Mendelson, Carole R (2009) cAMP enhances estrogen-related receptor alpha (ERRalpha) transcriptional activity at the SP-A promoter by increasing its interaction with protein kinase A and steroid receptor coactivator 2 (SRC-2). Mol Endocrinol 23:772-83
Liu, Dongyuan; Yi, Ming; Smith, Margaret et al. (2008) TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity. Am J Physiol Lung Cell Mol Physiol 295:L264-71
Islam, Kazi Nazrul; Mendelson, Carole R (2008) Glucocorticoid/glucocorticoid receptor inhibition of surfactant protein-A (SP-A) gene expression in lung type II cells is mediated by repressive changes in histone modification at the SP-A promoter. Mol Endocrinol 22:585-96
Liu, Dongyuan; Hinshelwood, Margaret M; Giguere, Vincent et al. (2006) Estrogen related receptor-alpha enhances surfactant protein-A gene expression in fetal lung type II cells. Endocrinology 147:5187-95
Islam, Kazi Nazrul; Mendelson, Carole R (2006) Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms. Mol Cell Biol 26:2901-12
Alcorn, Joseph L; Islam, Kazi N; Young, Pampee P et al. (2004) Glucocorticoid inhibition of SP-A gene expression in lung type II cells is mediated via the TTF-1-binding element. Am J Physiol Lung Cell Mol Physiol 286:L767-76
Gao, Erwei; Wang, Ying; Alcorn, Joseph L et al. (2003) Transcription factor USF2 is developmentally regulated in fetal lung and acts together with USF1 to induce SP-A gene expression. Am J Physiol Lung Cell Mol Physiol 284:L1027-36
Islam, Kazi Nazrul; Mendelson, Carole R (2002) Potential role of nuclear factor kappaB and reactive oxygen species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells. Mol Endocrinol 16:1428-40

Showing the most recent 10 out of 18 publications