This research project is designed to explore the concept that the mechanisms which regulate rapid eye movement (REM) and slow wave sleep (SWS) are modified in depressed individuals. Some of the abnormalities observed in the REM and NREM sleep of depressives appear to be """"""""episodic"""""""" and most often occur only during depressive episodes, whereas others are more """"""""persistent"""""""" and remain visible during well intervals. The sources of these abnormalities in the sleep EEG are unknown. We would suggest, however, that they involve such factors as genetic predisposition, chronophysiological mechanism, and the course of the illness itself and the interaction of course with aging and with both acute and maintenance antidepressant therapies. The proposed studies aim to evaluate empirically the effects of these factors on REM and SWS in depressives and to explore the impact of these factors on sleep regulation in normals. The following experimental goals are proposed: 1) to study intensively the evolution of antidepressant response and develop the capacity to identify the EEG sleep correlates of acute antidepressant response. We will pursue an expansion of our pulse-loading dose strategies with clorimipramine in acutely depressed in patients. Because of this agent's relatively long pharmacokinetic half-life, pharmacodynamic counter-clockwise hysteresis and potent suppression of serotonin reuptake, this strategy will provide an opportunity to examine the unfolding of antidepressant action on sleep EEG and clinical state; 2) To probe the REM and SWS systems with partial sleep deprivation in order to magnify and/or unmask underlying sleep EEG abnormalities in depressed patients during clinical recovery; 3) To continue the development of new methods of sleep EEG analysis in order to characterize specific critical parameters in the sleep of normals and depressed patients; 4) To evaluate the effects of age and sex on sleep architecture in well-screened normal subjects, studied both longitudinally and cross-sectionally; 5) To examine specific change sin REM and SWS as they unfold over the course of illness, recovery, and recurrence in the same patients; 6) To evaluate further the contribution of familial factors in the manifestation of various EEG sleep abnormalities in normals, depressed individuals, and their first-degree relatives.
| Brindle, Ryan C; Cribbet, Matthew R; Samuelsson, Laura B et al. (2018) The Relationship Between Childhood Trauma and Poor Sleep Health in Adulthood. Psychosom Med 80:200-207 |
| Irish, Leah A; Kline, Christopher E; Gunn, Heather E et al. (2015) The role of sleep hygiene in promoting public health: A review of empirical evidence. Sleep Med Rev 22:23-36 |
| Levenson, Jessica C; Kay, Daniel B; Buysse, Daniel J (2015) The pathophysiology of insomnia. Chest 147:1179-1192 |
| Gunn, Heather E; Troxel, Wendy M; Hall, Martica H et al. (2014) Interpersonal distress is associated with sleep and arousal in insomnia and good sleepers. J Psychosom Res 76:242-8 |
| Germain, Anne; Shear, Katherine M; Walsh, Colleen et al. (2013) Dream content in complicated grief: a window into loss-related cognitive schemas. Death Stud 37:269-84 |
| Levenson, Jessica C; Troxel, Wendy M; Begley, Amy et al. (2013) A quantitative approach to distinguishing older adults with insomnia from good sleeper controls. J Clin Sleep Med 9:125-31 |
| Wu, You Meme; Pietrone, Regina; Cashmere, J David et al. (2013) EEG power during waking and NREM sleep in primary insomnia. J Clin Sleep Med 9:1031-7 |
| Troxel, Wendy M; Conrad, Tyler S; Germain, Anne et al. (2013) Predictors of treatment response to brief behavioral treatment of insomnia (BBTI) in older adults. J Clin Sleep Med 9:1281-9 |
| Troxel, Wendy M; Kupfer, David J; Reynolds 3rd, Charles F et al. (2012) Insomnia and objectively measured sleep disturbances predict treatment outcome in depressed patients treated with psychotherapy or psychotherapy-pharmacotherapy combinations. J Clin Psychiatry 73:478-85 |
| Troxel, Wendy M; Germain, Anne; Buysse, Daniel J (2012) Clinical management of insomnia with brief behavioral treatment (BBTI). Behav Sleep Med 10:266-79 |
Showing the most recent 10 out of 137 publications
