The goal of the overall research project is to further our knowledge about schizophrenia and other major psychoses by a prospective longitudinal investigation involving a 15 year followup of a large sample of patients previously studied prospectively at the acute phase and already followed up four times over a ten year period. The following hypotheses about functioning and adjustment over time in schizophrenia, and about the course of positive and negative symptoms, will be addressed. Hypothesis 1: Contrary to recent hypotheses, modern-day schizophrenics still have relatively poor outcomes. Schizophrenics are vulnerable to a sustained disorder and not just to intermittent episodes. Hypothesis 2: Psychosis persists or recurs over time in schizophrenia, and in schizoaffective disorders, but remits in other psychotic disorders. Hypothesis 3: Negative-deficit symptoms persist in schizophrenia, and they identify a subgroup of poor outcome schizophrenics. The research involves a multi-faceted prospective, longitudinal investigation of the course of positive symptoms, negative symptoms, and major components of psychosocial functioning and adjustment over time, using a battery of structured interviews, performance tests, thought disorder measures, and behavioral ratings. A large sample of young, non-chronic schizophrenic and schizoaffective disorders, bipolar affective disorders, unipolar psychotic depressives, and non-psychotic disorders are being assessed longitudinally. Patients have been evaluated at the acute phase, during partial recovery, and are being followed up at various phases during the posthospital period, for delusions, hallucinations, disordered thinking, and negative symptoms. They also are being assessed for neurotic and affective symptoms, rehospitalization, and social and work adjustment. The data are used to evaluate a number of theories about psychoses, thought disorder, negative symptoms, prognostic factors, and to assess the long-term clinical course and level of functioning and adjustment in modern-day schizophrenia.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Method to Extend Research in Time (MERIT) Award (R37)
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Psychopathology and Clinical Biology Research Review Committee (PCB)
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University of Illinois at Chicago
Schools of Medicine
United States
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Harrow, M; Jobe, T H; Faull, R N (2014) Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study. Psychol Med 44:3007-16
Sarapas, Casey; Shankman, Stewart A; Harrow, Martin et al. (2013) Attention/processing speed prospectively predicts social impairment 18 years later in mood disorders. J Nerv Ment Dis 201:824-7
Goghari, V M; Harrow, M; Grossman, L S et al. (2013) A 20-year multi-follow-up of hallucinations in schizophrenia, other psychotic, and mood disorders. Psychol Med 43:1151-60
Harrow, Martin; Jobe, Thomas H (2013) Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery? Schizophr Bull 39:962-5
Sarapas, Casey; Shankman, Stewart A; Harrow, Martin et al. (2012) Parsing trait and state effects of depression severity on neurocognition: Evidence from a 26-year longitudinal study. J Abnorm Psychol 121:830-7
Kaplan, Kalman J; Harrow, Martin; Faull, Robert N (2012) Are there gender-specific risk factors for suicidal activity among patients with schizophrenia and depression? Suicide Life Threat Behav 42:614-27
Harrow, M; Jobe, T H; Faull, R N (2012) Do all schizophrenia patients need antipsychotic treatment continuously throughout their lifetime? A 20-year longitudinal study. Psychol Med 42:2145-55
Goldberg, Joseph F; Harrow, Martin (2011) A 15-year prospective follow-up of bipolar affective disorders: comparisons with unipolar nonpsychotic depression. Bipolar Disord 13:155-63
Burdick, K E; Goldberg, J F; Harrow, M (2010) Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up. Acta Psychiatr Scand 122:499-506
Shankman, Stewart A; Nelson, Brady D; Harrow, Martin et al. (2010) Does physical anhedonia play a role in depression? A 20-year longitudinal study. J Affect Disord 120:170-6

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