Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37MH028783-20
Application #
2244200
Study Section
Special Emphasis Panel (NSS)
Project Start
1977-01-01
Project End
1998-12-31
Budget Start
1996-02-15
Budget End
1996-12-31
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Other Basic Sciences
Type
Other Domestic Higher Education
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Wurtman, Richard J; Cansev, Mehmet; Sakamoto, Toshimasa et al. (2009) Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dendritic spines in rodent brain. World Rev Nutr Diet 99:71-96
Cansev, Mehmet; Marzloff, George; Sakamoto, Toshimasa et al. (2009) Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups. Dev Neurosci 31:181-92
Wurtman, R J; Cansev, M; Ulus, I H (2009) Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides. J Nutr Health Aging 13:189-97
Wurtman, Richard J; Ulus, Ismail H; Cansev, Mehmet et al. (2006) Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res 1088:83-92
Ulus, Ismail H; Watkins, Carol J; Cansev, Mehmet et al. (2006) Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. Cell Mol Neurobiol 26:563-77
Cansev, Mehmet (2006) Uridine and cytidine in the brain: their transport and utilization. Brain Res Rev 52:389-97
Pooler, Amy M; Xi, Shijun C; Wurtman, Richard J (2006) The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons. J Neurochem 97:716-23
Pooler, A M; Guez, D H; Benedictus, R et al. (2005) Uridine enhances neurite outgrowth in nerve growth factor-differentiated pheochromocytoma cells. Neuroscience 134:207-14
Cansev, Mehmet; Watkins, Carol J; van der Beek, Eline M et al. (2005) Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res 1058:101-8
Wurtman, Richard J (2005) Genes, stress, and depression. Metabolism 54:16-9

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