Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37MH029094-12A1
Application #
3486431
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1976-09-15
Project End
1993-06-30
Budget Start
1988-08-01
Budget End
1989-06-30
Support Year
12
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Frazer, A (2000) Norepinephrine involvement in antidepressant action. J Clin Psychiatry 61 Suppl 10:25-30
Daws, L C; Toney, G M; Gerhardt, G A et al. (1998) In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters. J Pharmacol Exp Ther 286:967-76
Daws, L C; Lopez, R; Frazer, A (1998) Effects of antidepressant treatment on inhibitory avoidance behavior and amygdaloid beta-adrenoceptors in rats. Neuropsychopharmacology 19:300-13
Frazer, A (1997) Pharmacology of antidepressants. J Clin Psychopharmacol 17 Suppl 1:2S-18S
Daws, L C; Toney, G M; Davis, D J et al. (1997) In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus. J Neurosci Methods 78:139-50
Frazer, A (1997) Antidepressants. J Clin Psychiatry 58 Suppl 6:9-25
Thielen, R J; Fangon, N B; Frazer, A (1996) 4-(2'-Methoxyphenyl)-1-[2'-[N-(2""-pyridinyl)-p-iodobenzamido]ethyl] piperazine and 4-(2'-methoxyphenyl)-1-[2'-[N-(2""-pyridinyl)-p- fluorobenzamido]ethyl]piperazine, two new antagonists at pre- and postsynaptic serotonin-1A receptors. J Pharmacol Exp Ther 277:661-70
Kovachich, G B; Frazer, A; Aronson, C E (1993) Effect of chronic administration of antidepressants on alpha 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography. Neuropsychopharmacology 8:57-65
Tejani-Butt, S M (1992) [3H]nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding. J Pharmacol Exp Ther 260:427-36
Kovachich, G B; Aronson, C E; Brunswick, D J (1992) Effect of repeated administration of antidepressants on serotonin uptake sites in limbic and neocortical structures of rat brain determined by quantitative autoradiography. Neuropsychopharmacology 7:317-24

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