Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37MH036262-15
Application #
2244475
Study Section
Special Emphasis Panel (NSS)
Project Start
1982-05-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
15
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Cryan, John F; Page, Michelle E; Lucki, Irwin (2005) Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment. Psychopharmacology (Berl) 182:335-44
Hoshaw, Brian A; Malberg, Jessica E; Lucki, Irwin (2005) Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects. Brain Res 1037:204-8
Cryan, John F; Valentino, Rita J; Lucki, Irwin (2005) Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev 29:547-69
Cryan, John F; O'Leary, Olivia F; Jin, Sung-Ha et al. (2004) Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors. Proc Natl Acad Sci U S A 101:8186-91
Page, Michelle E; Brown, Kevin; Lucki, Irwin (2003) Simultaneous analyses of the neurochemical and behavioral effects of the norepinephrine reuptake inhibitor reboxetine in a rat model of antidepressant action. Psychopharmacology (Berl) 165:194-201
Cryan, John F; Page, Michelle E; Lucki, Irwin (2002) Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test. Eur J Pharmacol 436:197-205
Rittenhouse, Peter A; Lopez-Rubalcava, Carolina; Stanwood, Gregg D et al. (2002) Amplified behavioral and endocrine responses to forced swim stress in the Wistar-Kyoto rat. Psychoneuroendocrinology 27:303-18
Price, Michelle L; Kirby, Lynn G; Valentino, Rita J et al. (2002) Evidence for corticotropin-releasing factor regulation of serotonin in the lateral septum during acute swim stress: adaptation produced by repeated swimming. Psychopharmacology (Berl) 162:406-14
Lucki, I; Dalvi, A; Mayorga, A J (2001) Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology (Berl) 155:315-22
Lopez-Rubalcava, C; Lucki, I (2000) Strain differences in the behavioral effects of antidepressant drugs in the rat forced swimming test. Neuropsychopharmacology 22:191-9

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