Two subtypes of schizophrenia are proposed: early onset male schizophrenics characterized by poor premorbid history, little affect and poor long-term outcome; late onset female schizophrenics characterized by good premorbid history, prominent affect and good long-term outcome. It is hypothesized that neural dysfunctions are particularly characteristic of schizophrenia in men and may be important in the further delineation of subgroups to reduce intragroup heterogeneity in schizophrenia. To test this, 100 DSM- III R schizophrenic patients will be divided into sex by onset age groups and assessed for brain anatomic abnormalities (using magnetic resonance imaging), psychoneurological impairment (both lateralized and interhemispheric transfer deficits), and psychiatric symptoms (positive and negative). Emphasis will be on the corpus callosum, lateral ventricles and frontal cortex. It is generally expected that early onset male schizophrenics will evidence the most structural abnormality and performance impairment, both of which will be associated with negative symptoms. This study will help elucidate the nature of sexual dimorphism in brain structure, the relationship between structural size and shape variation and function, and the role of neural deviation in the further refinement of schizophrenia subtyping.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37MH044151-07
Application #
2245999
Study Section
Special Emphasis Panel (NSS)
Project Start
1989-04-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1996-03-31
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Emory University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Brewerton, Timothy D; Putnam, Karen T; Lewine, Richard R J et al. (2018) Seasonality of cerebrospinal fluid monoamine metabolite concentrations and their associations with meteorological variables in humans. J Psychiatr Res 99:76-82
Lewine, Richard; Martin, Morgan; Hart, Mara (2017) Sex versus gender differences in schizophrenia: The case for normal personality differences. Schizophr Res 189:57-60
Thurston-Snoha, Bonnie-Jean; Lewine, Richard R J (2007) Intact Wisconsin Card Sorting Test performance: implications for the role of executive function in schizophrenia. Br J Clin Psychol 46:361-9
Lewine, Richard R J; Thurston-Snoha, Bonnie-Jean; Ardery, Rose (2006) Sex, gender, and neuropsychological functioning in schizophrenia. J Clin Exp Neuropsychol 28:1362-72
Parrott, Brooke; Lewine, Rich (2005) Socioeconomic status of origin and the clinical expression of Schizophrenia. Schizophr Res 75:417-24
Hochman, Karen M; Lewine, Richard R (2004) Age of menarche and schizophrenia onset in women. Schizophr Res 69:183-8
Lewine, Rich (2004) At issue: Sex and gender in schizophrenia. Schizophr Bull 30:755-62
Lewine, R R; Caudle, J (2000) Racial effects on neuropsychological functioning in schizophrenia. Am J Psychiatry 157:2038-40
Scheller-Gilkey, G; Lewine, R R; Caudle, J et al. (1999) Schizophrenia, substance use, and brain morphology. Schizophr Res 35:113-20
Scheller-Gilkey, G; Lewine, R R (1999) Age at onset and sex differences in corpus callosum area in schizophrenia. Schizophr Res 40:229-35

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