The major objectives of this study are to: 1) confirm reports that cases with onset of schizophrenia prior to 13 years of age have an increased aggregation of schizophrenia and schizophrenia spectrum personality disorders in their families as compared to cases of adult onset schizophrenia, 2) test the hypothesis that certain measures of attention/information processing (AIP) index a genetic liability to schizophrenic disorder, 3) determine if the distribution of AIP impairments amongst the first degree relatives of schizophrenic children is consistent with a simple model of genetic transmission, and 4) test the hypothesis that performance on certain AIP tasks provides a useful basis for sub-typing schizophrenic patients by determining if schizophrenic children with and without AIP impairments differ in their short term response to neuroleptic treatment, incidence of minor physical anomalies, familial aggregation of schizophrenic spectrum disorders and in ratings of formal thought disorder and the frequency of parental communication deviance. Seventy five families in each of three groups will be studied: 1) families with a schizophrenic child, 2) families with an attention deficit disorder child, and 3) families with children who have no history of psychiatric disorder. Children with an attention deficit disorder provide a test of the diagnostic specificity of the above relations. Proband will be diagnosed with a structured diagnostic interview and rated on a measure of formal thought disorder. AIP performance will be evaluated and minor physical anomalies measured in all proband and their first degree relatives. First degree relatives will be administered structured diagnostic interviews to make DSM III axis I diagnoses and diagnoses of schizophrenic spectrum personality disorders, and psychometric measures of psychosis proneness. Family history of schizophrenic disorders will be determined for second and third degree relatives. All assessments of first degree relatives will be conducted by staff blind to the proband's diagnosis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37MH045112-04
Application #
2246391
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1989-08-01
Project End
1993-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Other Domestic Higher Education
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Chen, Qiaolin; Sugar, Catherine A; Weiss, Robert E (2018) A Bayesian confirmatory factor model for multivariate observations in the form of two-way tables of data. Stat Med 37:1696-1710
Fernandez, Vindia G; Asarnow, Robert; Narr, Katherine L et al. (2018) Temporal lobe thickness and verbal memory in first-degree relatives of individuals with schizophrenia. Schizophr Res 199:221-225
Fogelson, D L; Asarnow, R A; Sugar, C A et al. (2010) Avoidant personality disorder symptoms in first-degree relatives of schizophrenia patients predict performance on neurocognitive measures: the UCLA family study. Schizophr Res 120:113-20
Subotnik, Kenneth L; Asarnow, Robert F; Nuechterlein, Keith H et al. (2005) MMPI vulnerability indicators for schizophrenia and attention deficit disorder: UCLA family study of biological parents of offspring with childhood-onset schizophrenia or ADHD. Behav Genet 35:159-75
Fogelson, David L; Nuechterlein, Keith H; Asarnow, Robert F et al. (2004) Validity of the family history method for diagnosing schizophrenia, schizophrenia-related psychoses, and schizophrenia-spectrum personality disorders in first-degree relatives of schizophrenia probands. Schizophr Res 68:309-17
Asarnow, Robert F; Nuechterlein, Keith H; Asamen, Joy et al. (2002) Neurocognitive functioning and schizophrenia spectrum disorders can be independent expressions of familial liability for schizophrenia in community control children: the UCLA family study. Schizophr Res 54:111-20
Nuechterlein, Keith H; Asarnow, Robert F; Subotnik, Kenneth L et al. (2002) The structure of schizotypy: relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family Study. Schizophr Res 54:121-30
Subotnik, Kenneth L; Goldstein, Michael J; Nuechterlein, Keith H et al. (2002) Are communication deviance and expressed emotion related to family history of psychiatric disorders in schizophrenia? Schizophr Bull 28:719-29
Asarnow, Robert F; Nuechterlein, Keith H; Subotnik, Kenneth L et al. (2002) Neurocognitive impairments in nonpsychotic parents of children with schizophrenia and attention-deficit/hyperactivity disorder: the University of California, Los Angeles Family Study. Arch Gen Psychiatry 59:1053-60
Asarnow, R F; Nuechterlein, K H; Fogelson, D et al. (2001) Schizophrenia and schizophrenia-spectrum personality disorders in the first-degree relatives of children with schizophrenia: the UCLA family study. Arch Gen Psychiatry 58:581-8

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