Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37NS021045-21
Application #
6795464
Study Section
Special Emphasis Panel (NSS)
Program Officer
Jacobs, Tom P
Project Start
1985-07-01
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
21
Fiscal Year
2004
Total Cost
$513,947
Indirect Cost
Name
Washington University
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Stowe, Ann M; Adair-Kirk, Tracy L; Gonzales, Ernesto R et al. (2009) Neutrophil elastase and neurovascular injury following focal stroke and reperfusion. Neurobiol Dis 35:82-90
Zhang, Yunhong; Park, Tae S; Gidday, Jeffrey M (2007) Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation. Am J Physiol Heart Circ Physiol 292:H2573-81
Altay, Tamer; McLaughlin, Bethann; Wu, Jane Y et al. (2007) Slit modulates cerebrovascular inflammation and mediates neuroprotection against global cerebral ischemia. Exp Neurol 207:186-94
Gidday, Jeffrey M; Gasche, Yvan G; Copin, Jean-C et al. (2005) Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol 289:H558-68
Zhang, Yunhong; Zhang, Xiaochun; Park, Tae S et al. (2005) Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation. J Cereb Blood Flow Metab 25:868-77
Kaplan, S S; Park, T S; Gonzales, E R et al. (2000) Hydroxyethyl starch reduces leukocyte adherence and vascular injury in the newborn pig cerebral circulation after asphyxia. Stroke 31:2218-23
Gidday, J M; Kim, Y B; Shah, A R et al. (1996) Adenosine transport inhibition ameliorates postischemic hypoperfusion in pigs. Brain Res 734:261-8
Park, T S; Gonzales, E R; Shah, A R et al. (1995) Hypoglycemia selectively abolishes hypoxic reactivity of pial arterioles in piglets: role of adenosine. Am J Physiol 268:H871-8
Ruth, V J; Park, T S; Gonzales, E R et al. (1993) Adenosine and cerebrovascular hyperemia during insulin-induced hypoglycemia in newborn piglet. Am J Physiol 265:H1762-8
Gidday, J M; Park, T S (1992) Effect of 2-chloroadenosine on cerebrovascular reactivity to hypercapnia in newborn pig. J Cereb Blood Flow Metab 12:656-63

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