Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37NS032103-10
Application #
6908650
Study Section
Special Emphasis Panel (NSS)
Program Officer
Jacobs, Tom P
Project Start
1993-08-01
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
10
Fiscal Year
2004
Total Cost
$382,500
Indirect Cost

  Institution

Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048

  Publications

Black, Keith L; Yin, Dali; Ong, John M et al. (2008) PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model. Brain Res 1230:290-302
Black, Keith L; Yin, Dali; Konda, Bindu M et al. (2008) Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models. Brain Res 1227:198-206
Hu, Jinwei; Yuan, Xiangpeng; Ko, MinHee K et al. (2007) Calcium-activated potassium channels mediated blood-brain tumor barrier opening in a rat metastatic brain tumor model. Mol Cancer 6:22
Black, Keith L; Ningaraj, Nagendra S (2004) Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor. Cancer Control 11:165-73
Ningaraj, Nagendra S; Rao, Mamatha; Black, Keith L (2003) Calcium-dependent potassium channels as a target protein for modulation of the blood-brain tumor barrier. Drug News Perspect 16:291-8
Asotra, Kamlesh; Ningaraj, Nagendra; Black, Keith L (2003) Measurement of blood-brain and blood-tumor barrier permeabilities with [14C]-labeled tracers. Methods Mol Med 89:177-90
Ningaraj, Nagendra S; Rao, Mamatha K; Black, Keith L (2003) Adenosine 5'-triphosphate-sensitive potassium channel-mediated blood-brain tumor barrier permeability increase in a rat brain tumor model. Cancer Res 63:8899-911
Uchida, Mikito; Chen, Zutang; Liu, Yunhui et al. (2002) Overexpression of bradykinin type 2 receptors on glioma cells enhances bradykinin-mediated blood-brain tumor barrier permeability increase. Neurol Res 24:739-46
Ningaraj, Nagendra S; Rao, Mamatha; Hashizume, Kazuhiro et al. (2002) Regulation of blood-brain tumor barrier permeability by calcium-activated potassium channels. J Pharmacol Exp Ther 301:838-51