Opening of the Blood Brain Barrier to Antitumor Agents

Neuwelt, Edward A.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37NS044687-23
• Application #: 6894787
• Study Section: Special Emphasis Panel (ZRG1-BDCN-2 (07))
• Program Officer: Jacobs, Tom P
• Project Start: 1988-02-01
• Project End: 2006-04-30
• Budget Start: 2005-05-01
• Budget End: 2006-04-30
• Support Year: 23
• Fiscal Year: 2005
• Total Cost: $395,717

Institution

• Name: Oregon Health and Science University
• Department: Neurology
• Type: Schools of Medicine
• DUNS #: 096997515
• City: Portland
• State: OR
• Country: United States
• Zip Code: 97239

Publications

Ambady, Prakash; Szidonya, Laszlo; Firkins, Jenny et al. (2018) Combination immunotherapy as a non-chemotherapy alternative for refractory or recurrent CNS lymphoma. Leuk Lymphoma :1-4

Netto, Joao Prola; Schwartz, Daniel; Varallyay, Csanad et al. (2016) Misleading early blood volume changes obtained using ferumoxytol-based magnetic resonance imaging perfusion in high grade glial neoplasms treated with bevacizumab. Fluids Barriers CNS 13:23

McConnell, Heather L; Schwartz, Daniel L; Richardson, Brian E et al. (2016) Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific. Nanomedicine 12:1535-42

Muldoon, Leslie L; Pagel, Michael A; Netto, Joao Prola et al. (2016) Intra-arterial administration improves temozolomide delivery and efficacy in a model of intracerebral metastasis, but has unexpected brain toxicity. J Neurooncol 126:447-54

Muldoon, Leslie L; Wu, Y Jeffrey; Pagel, Michael A et al. (2015) N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models. J Neurooncol 121:433-40

Lal, Sangeet; Kersch, Cymon; Beeson, Kathleen A et al. (2015) Interactions between ?v-Integrin and HER2 and Their Role in the Invasive Phenotype of Breast Cancer Cells In Vitro and in Rat Brain. PLoS One 10:e0131842

Pishko, Gregory L; Muldoon, Leslie L; Pagel, Michael A et al. (2015) Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis. Fluids Barriers CNS 12:5

Doolittle, Nancy D; Muldoon, Leslie L; Culp, Aliana Y et al. (2014) Delivery of chemotherapeutics across the blood-brain barrier: challenges and advances. Adv Pharmacol 71:203-43

Gahramanov, Seymur; Varallyay, Csanad; Tyson, Rose Marie et al. (2014) Diagnosis of pseudoprogression using MRI perfusion in patients with glioblastoma multiforme may predict improved survival. CNS Oncol 3:389-400

Farrell, Brian T; Hamilton, Bronwyn E; Dósa, Edit et al. (2013) Using iron oxide nanoparticles to diagnose CNS inflammatory diseases and PCNSL. Neurology 81:256-63