1st Playable Productions and Union College propose to develop a commercializable product combining physical exercise and cognitive activities through interactive gaming on a stationary bicycle to help prevent cognitive decline and dementia in older adults. The Interactive Physical and Cognitive Exercise System (iPACES) developed by Union College's Healthy Aging and Neuropsychology Lab is the first system to combine physical and cognitive interventions, and has already proven to have a greater cognitive benefit to older adults than either of these two interventions alone. While behavioral interventions are unlikely to completely prevent or halt dementia, there is the potential for synergistic physical and cognitive exercise specifically to reduce the risk of onset dementia or slow progression. Creating an affordable and easily distributed product will enable wide access to this intervention, while also furthering understanding of what combinations have biggest impact. This Phase I project includes the development of a game that combines physical and cognitive exercise, a hardware configuration that is safe for older adults and suited for in-home installation, and the further collection of user data to inform further developments in engaging design. Participants will be recruited from area retirement communities and advertising and screened for suitability. Participants are assessed after two weeks of playing the cognitive game, without exercise, then as participants engage in the full experience they are assessed at 2, 6, and 12 weeks. Normative individuals interested in maintaining brain health, patients who are prescribed iPACES to slow or ameliorate cognitive decline, retirement and assisted living communities are all potential beneficiaries of the dementia treatment. The incidence of dementia in North America is projected to nearly triple from 3.4 million cases in 2001 to 9.2 million by 2040, with a worldwide increase from 24 to 81 million over the same time period. Considering multiple causes of dementia, no known cure, and minimal benefit from medication, behavioral interventions to improve brain health are a critical component for extending quality of life for patients, families, and their support systems.

Public Health Relevance

Memory Lane (c) is a neuro-exergame that utilizes an interactive physical and cognitive exercise system (iPACES (c)) to help prevent or ameliorate cognitive decline and dementia in older adults. This project extends prior research on the benefits of interactive phsycial and cognitive exercise (Anderson-Hanley et al., 2012) as well as promising preliminary data from a single bout pilot study using Memory Lane with older adults which found greater cognitive benefit of neuro- exergaming than either exercise or gaming alone (Anderson-Hanley, 2015). The goal is create an accessible easily distributed product that can protect against and ameliorate cognitive decline, to improve quality of life for an aging population.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Business Technology Transfer (STTR) Grants - Phase I (R41)
Project #
1R41AG053120-01
Application #
9138532
Study Section
Special Emphasis Panel (ZRG1-RPHB-R (12)B)
Program Officer
Ryan, Laurie M
Project Start
2016-09-15
Project End
2017-08-31
Budget Start
2016-09-15
Budget End
2017-08-31
Support Year
1
Fiscal Year
2016
Total Cost
$149,999
Indirect Cost
Name
1st Playable Productions, LLC
Department
Type
DUNS #
787314058
City
Troy
State
NY
Country
United States
Zip Code
12180