This application proposes a new method for imaging medical devices that can contain amorphous ferromagnetic materials. Potential devices include Fiducial markers, surgical clips, catheters, and brachytherapy-seeds. The procedure would not require radioactive materials and would be relatively insensitive to inhomogeneities. Small array- or stereologic-detectors would have resolutions of about one mm to 20-cm depths. Individual detectors would be about the size of a pen and a hand-held stereologic detector about the size of a cell phone. First clinical applications will be real-time imaging of Fiducial markers and then surgical clips. Fiducial markers are used throughout radiation oncology for localization of the patient and treatment volume. Surgical clips are used to delineate the surgical bed or tumor volume for subsequent radiation treatments. Both methods normally require prior imaging, sometimes days before. Other applications include patient contouring for gating and intensity modulated radiotherapy and accurately locating brachytherapy seeds, catheters, and stents during treatment. This technique will reduce the number of CT or fluroscopic images and associated radiation doses to patient and staff. Existing reconstruction techniques will be adapted to provide absolute spatial information. With fusion, images can be combined with CT, MRI, or PET for anatomical and physiological information.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Small Business Technology Transfer (STTR) Grants - Phase I (R41)
Project #
1R41EB000621-01A1
Application #
6738905
Study Section
Special Emphasis Panel (ZRG1-SSS-7 (10))
Program Officer
Mclaughlin, Alan Charles
Project Start
2003-09-25
Project End
2007-08-31
Budget Start
2003-09-25
Budget End
2007-08-31
Support Year
1
Fiscal Year
2003
Total Cost
$105,489
Indirect Cost
Name
Biomed Innovations, LLC
Department
Type
DUNS #
174404561
City
Timonium
State
MD
Country
United States
Zip Code
21093