Neuro-inflammation is thought to be an important factor in age-dependent loss of neuron associated with Alzheimer's disease. We seek STTR funding to develop a unique transgenic rat that serves as a model for chronic neuro-inflammation and age-dependent loss of neurons. Presently, no other animal model offers specific patterns of neuro-inflammation, presence of inflammatory cell-derived neurotoxins, and measurable age-dependent losses of neocortical neurons that closely match the pathology found in human brain during early AIzheimer's disease (AD). We believe that the novel rat model described here will have significant commercial potential among academic institutions and government agencies investigating mechanisms of AD pathology and among pharmaceutical and biotechnological companies testing drugs for treatment of AD.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Business Technology Transfer (STTR) Grants - Phase II (R42)
Project #
1R42AG022805-01
Application #
6695365
Study Section
Special Emphasis Panel (ZRG1-SSS-S (11))
Program Officer
Snyder, Stephen D
Project Start
2003-09-30
Project End
2004-08-31
Budget Start
2003-09-30
Budget End
2004-08-31
Support Year
1
Fiscal Year
2003
Total Cost
$548,811
Indirect Cost
Name
Inflame Therapeutics, Inc.
Department
Type
DUNS #
170628619
City
Houston
State
TX
Country
United States
Zip Code
77054