Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Small Business Technology Transfer (STTR) Grants - Phase II (R42)
Project #
9R42ES011746-02
Application #
6440100
Study Section
Special Emphasis Panel (ZCA1-SRRB-U (O1))
Program Officer
Heindel, Jerrold
Project Start
2002-04-01
Project End
2005-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
2
Fiscal Year
2002
Total Cost
$496,681
Indirect Cost
Name
Eno River Labs, LLC
Department
Type
DUNS #
146017269
City
Durham
State
NC
Country
United States
Zip Code
27713
Mutlu, Esra; Jeong, Yo-Chan; Collins, Leonard B et al. (2012) A new LC-MS/MS method for the quantification of endogenous and vinyl chloride-induced 7-(2-Oxoethyl)guanine in sprague-dawley rats. Chem Res Toxicol 25:391-9
Begemann, Petra; Boysen, Gunnar; Georgieva, Nadia I et al. (2011) Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro. Chem Res Toxicol 24:1048-61
Asagoshi, Kenjiro; Tano, Keizo; Chastain 2nd, Paul D et al. (2010) FEN1 functions in long patch base excision repair under conditions of oxidative stress in vertebrate cells. Mol Cancer Res 8:204-15
Mutlu, Esra; Collins, Leonard B; Stout, Matthew D et al. (2010) Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N(2),3-ethenoguanine in tissues of adult and weanling rats following exposure to [(13)C(2)]-VC. Chem Res Toxicol 23:1485-91
Baskerville-Abraham, Irene M; Boysen, Gunnar; Troutman, J Mitchell et al. (2009) Development of an ultraperformance liquid chromatography/mass spectrometry method to quantify cisplatin 1,2 intrastrand guanine-guanine adducts. Chem Res Toxicol 22:905-12
Jeong, Yo-Chan; Walker, Nigel J; Burgin, Deborah E et al. (2008) Accumulation of M1dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons. Free Radic Biol Med 45:585-91
Stout, Matthew D; Bodes, Elmarie; Schoonhoven, Robert et al. (2008) Toxicity, DNA binding, and cell proliferation in male F344 rats following short-term gavage exposures to trans-2-hexenal. Toxicol Pathol 36:232-46
Swenberg, James A; Boysen, Gunnar; Georgieva, Nadia et al. (2007) Future directions in butadiene risk assessment and the role of cross-species internal dosimetry. Chem Biol Interact 166:78-83
Georgieva, Nadia I; Boysen, Gunnar; Upton, Patricia B et al. (2007) Quantitative analysis of N-terminal valine peptide adducts specific for 1,2-epoxy-3-butene. Chem Biol Interact 166:219-25
Tano, Keizo; Nakamura, Jun; Asagoshi, Kenjiro et al. (2007) Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. DNA Repair (Amst) 6:869-75

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