Human cytomegalovirus (HCMV) associated disease is responsible for over $10 billion in healthcare costs annually in the US. Mental retardation and hearing impairment caused by congenital CMV infection, and organ transplant rejection and MDS associated CMV retinitis and colitis are preventable diseases. However, no vaccine currently exists for prevention of HCMV disease and most inactivated or subunit approaches have failed. Aviron's objective is to develop a safe, live, attenuated HCMV vaccine for universal childhood immunization. Vaccination of seronegative persons prior to immunosuppression for organ transplantation or HIV infection may also prevent the morbidity and mortality of severe HCMV disease in the immunocompromised host. The goal of the research proposed in the Phase l SBIR application is to apply recent innovative advances in mucoaal vaccine delivery and virus detection to understand the human host's response to acute CMV infection and immunization. These data will be used to determine if a set of four specifically designed, reombinant, live HCMV vaccine candidates when delivered to the naso-, oral mucosal surface elicits humoral and cell-based responses that are likely to provide protection from the sequelae of HCMV infection.

Proposed Commercial Applications

An effective, live attenuated HCMV vaccine should prevent mental retardation and hearing impairment associated with HCMV congenital disease. There are no preventative or therapeutic regimens available to reduce HCMV congenital disease, therefore, the live HCMV vaccine addresses an unmet public health

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
5R43AI045176-02
Application #
6335438
Study Section
Special Emphasis Panel (ZRG1-VACC (02))
Program Officer
Beisel, Christopher E
Project Start
1999-09-30
Project End
2001-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
2
Fiscal Year
2000
Total Cost
$267,059
Indirect Cost
Name
Medimmune Vaccines, Inc.
Department
Type
DUNS #
City
Mountain View
State
CA
Country
United States
Zip Code
94043