Polyurethanes are used in a variety of biomedical devices including artificial hearts, vascular grafts, catheters, and intra-aortic balloons. This proposal presents methods for the synthesis, characterization, and fabrication of polyurethaneurea (PUU) Primary Reference Materials (PRM). The proposed program involves the synthesis of a batch of additive-free PTMO based polyurethaneurea and a batch of additive-free PEO based polyurethaneurea followed by thorough characterization of the bulk and surface properties of cast films. Polymers that are free of unwanted surface active contaminants, as determined by ESCA and static SIMS, will be fabricated into film samples, 1 x 3 x 0.005 inches, and will be packaged, sterilized and characterized. Tubing extrusion methods will be evaluated for producing small diameter tubing samples with a 4 mm ID and 10 cm long. A feasibility study will be performed to determine if it is possible to fabricate implantable quality small diameter tubing 0.5 meter long. The effect of gamma radiation on physicochemical properties of polyurethaneureas will be determined. Changes in the surface properties of the PRM as a function of time/annealing will be assessed.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43HL049703-01
Application #
2225773
Study Section
Special Emphasis Panel (SSS (B4))
Project Start
1993-04-01
Project End
1994-04-14
Budget Start
1993-04-01
Budget End
1994-04-14
Support Year
1
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Polymer Technology Group, Inc.
Department
Type
DUNS #
City
Berkeley
State
CA
Country
United States
Zip Code
94710