Occluder dynamics and valve hemodynamics in mechanical heart valves (MHV's) are strongly coupled. We propose to develop a numerical fluid- structure interaction model for predicting leaflet dynamics as a function of the flow field at physiologic flow rates in-tilting disk mitral MHV's. The Influence-Coefficient method, which we earlier used to model flow- structure interactions in natural aortic valves, will be adapted for simulating mitral MHV dynamics. In Phase I, a two-dimensional computer model will be developed for a typical bi-leaflet valves. The model will be used to study valve hemodynamics and cavitation inception near the valve. Published in-vitro data on valve closure velocity and clinical data on the sites for cavitation damage in MHV explants will be used to assess and refine the model predictions. In Phase II, the model will be adapted for mono-leaflet tilting disk valves, and then extended for three-dimensional (3-D) simulations. The 3-D model will be validated in collaboration with a leading experimental research group. It will then be used to develop the design criteria for tilting disk mitral MHVs with improved hemodynamics in which cavitation is eliminated.

Proposed Commercial Applications

The developed model would be valuable design tools for companies designing and manufacturing mechanical heart valves. It would serve as a computational test chamber for current and future MHV designs. It would be of interest to manufacturers of left ventricular assist devices (LVAD's) and pulsatile blood pumps in which cavitation damage has been reported. The developed software will be suitable for running on workstations, which are within the financial budgets of LVAD and valve manufacturers.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43HL050923-01A2
Application #
2227282
Study Section
Special Emphasis Panel (ZRG7-SSS-W (06))
Project Start
1995-09-01
Project End
1996-05-31
Budget Start
1995-09-01
Budget End
1996-05-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Cfd Research Corporation
Department
Type
DUNS #
185169620
City
Huntsville
State
AL
Country
United States
Zip Code
35805