The overall goal of this project is to develop and commercialize a new sensor system for patient monitoring that will measure both oxygen and carbon dioxide in the muscle. These measurements can be used to predict the early onset of hemorrhagic shock, quantify the efficacy of cardiac resuscitation, and improve the standard of care for critically ill patients. To accomplish this goal, novel technology will be utilized to make very small and highly accurate sensors for measuring oxygen or carbon dioxide in tissue. These sensors will not require on site calibration and can be easily and quickly implanted in tissue. The sensor systems will be small and robust, weighing only a few ounces and they will be battery operated. The sensor system is intended to perform reliably in the field under difficult conditions as well as in fully equipped medical facilities. Care will be taken at every level to assure optimal performance, ease of use, and tight integration into the applicable clinical environment. This sensor system will substantially improve the care of critically ill patients, particularly those suffering from acute trauma.

Public Health Relevance

This proposal will result in a medical device that will improve the monitoring capabilities for critical care patients and for patients undergoing CPR. The device will accurately monitor oxygen levels in muscle to give an accurate measure of how the circulation is functioning. The product is designed to be used by first responders in field situations, and in the ICU.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43HL103358-01
Application #
7927873
Study Section
Special Emphasis Panel (ZRG1-CVRS-B (53))
Program Officer
Baldwin, Tim
Project Start
2010-06-01
Project End
2012-05-31
Budget Start
2010-06-01
Budget End
2012-05-31
Support Year
1
Fiscal Year
2010
Total Cost
$199,744
Indirect Cost
Name
Oxygense, LLC
Department
Type
DUNS #
829802987
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Wilson, David F; Vinogradov, Sergei A; Schears, Gregory J et al. (2012) Monitoring cardiopulmonary function and progression toward shock: oxygen micro-sensor for peripheral tissue. Adv Exp Med Biol 737:221-7